DNA Walker-Regulated Cancer Cell Growth Inhibition

Feiran Li, Tae Gon Cha, Jing Pan, Altug Ozcelikkale, Bumsoo Han, Jong Hyun Choi

Research output: Contribution to journalArticlepeer-review

Abstract

We demonstrate a DNAzyme-based walker system as a controlled oligonucleotide drug AS1411 release platform for breast cancer treatment. In this system, AS1411 strands are released from fuel strands as a walker moves along its carbon nanotube track. The release rate and amount of anticancer oligonucleotides are controlled by the walker operation. With a walker system embedded within the collagen extracellular matrix, we show that this drug release system can be used for in situ cancer cell growth inhibition.

Original languageEnglish (US)
Pages (from-to)1138-1141
Number of pages4
JournalChemBioChem
DOIs
StatePublished - Jun 16 2016
Externally publishedYes

Keywords

  • anticancer
  • DNA walker
  • DNAzyme
  • growth inhibition
  • oligonucleotides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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