Abstract
We demonstrate a DNAzyme-based walker system as a controlled oligonucleotide drug AS1411 release platform for breast cancer treatment. In this system, AS1411 strands are released from fuel strands as a walker moves along its carbon nanotube track. The release rate and amount of anticancer oligonucleotides are controlled by the walker operation. With a walker system embedded within the collagen extracellular matrix, we show that this drug release system can be used for in situ cancer cell growth inhibition.
Original language | English (US) |
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Pages (from-to) | 1138-1141 |
Number of pages | 4 |
Journal | ChemBioChem |
DOIs | |
State | Published - Jun 16 2016 |
Externally published | Yes |
Keywords
- anticancer
- DNA walker
- DNAzyme
- growth inhibition
- oligonucleotides
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Organic Chemistry