Efficient near-infrared detection of specific DNA with single nucleotide polymorphism selectivity is important for diagnostics and biomedical research. Herein, we report the use of gallium arsenide (GaAs) as a sensing platform for probing DNA immobilization and targeting DNA hybridization, resulting in ∼8-fold enhanced GaAs photoluminescence (PL) at ∼875 nm. The new signal amplification strategy, further coupled with the plasmonic effect of Au nanoparticles, is capable of detecting DNA molecules with a detection limit of 0.8 pM and selectivity against single base mismatches. Such an ultrasensitive near-infrared sensor can find a wide range of biochemical and biomedical applications.

Original languageEnglish (US)
Pages (from-to)9522-9527
Number of pages6
JournalAnalytical Chemistry
Issue number20
StatePublished - Oct 15 2013

ASJC Scopus subject areas

  • Analytical Chemistry

Fingerprint Dive into the research topics of 'DNA detection using plasmonic enhanced near-infrared photoluminescence of gallium arsenide'. Together they form a unique fingerprint.

Cite this