Abstract
Efficient near-infrared detection of specific DNA with single nucleotide polymorphism selectivity is important for diagnostics and biomedical research. Herein, we report the use of gallium arsenide (GaAs) as a sensing platform for probing DNA immobilization and targeting DNA hybridization, resulting in ∼8-fold enhanced GaAs photoluminescence (PL) at ∼875 nm. The new signal amplification strategy, further coupled with the plasmonic effect of Au nanoparticles, is capable of detecting DNA molecules with a detection limit of 0.8 pM and selectivity against single base mismatches. Such an ultrasensitive near-infrared sensor can find a wide range of biochemical and biomedical applications.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 9522-9527 |
| Number of pages | 6 |
| Journal | Analytical Chemistry |
| Volume | 85 |
| Issue number | 20 |
| DOIs | |
| State | Published - Oct 15 2013 |
ASJC Scopus subject areas
- Analytical Chemistry