DNA-cationic amphiphile interactions

Maria G. Miguel, Alberto A.C.C. Pais, Rita S. Dias, Cecília Leal, Mónica Rosa, Björn Lindman

Research output: Contribution to journalArticlepeer-review


DNA shows strong interactions with cationic cosolutes and these have both biological and technological significance. We outline our research on various mixed systems of DNA and cationic amphiphiles including the interaction of DNA with simple cationic surfactants as well as the interaction with catanionic mixtures and positively charged catanionic vesicles. An overview from phase behavior to microstructure will be presented. We will also address DNA compaction and decompaction phenomena in different systems. Finally, simulations on DNA confinement and interaction with cationic polyions are considered.

Original languageEnglish (US)
Pages (from-to)43-55
Number of pages13
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Issue number1-3
StatePublished - Nov 1 2003
Externally publishedYes


  • Amino acid-based surfactants
  • Catanionic mixtures
  • Catanionic vesicles
  • Cationic amphiphiles/surfactants
  • Cryo-TEM
  • DNA
  • DNA compaction/decompaction
  • DNA hydration
  • DNA-amphiphile complexes
  • Fluorescence microscopy
  • Phase behavior
  • Polyions

ASJC Scopus subject areas

  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry


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