Abstract
A new reaction for DNA: DNA is shown to catalyze Ni2+-dependent reductive amination involving the N2-amine of a guanosine nucleobase (see picture). This finding expands the repertoire of nucleic acid catalysis to include reductive amination, an important natural biosynthetic reaction that has practical synthetic utility.
Original language | English (US) |
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Pages (from-to) | 11679-11684 |
Number of pages | 6 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 49 |
DOIs | |
State | Published - Dec 2 2011 |
Keywords
- DNA
- deoxyribozymes
- enzyme catalysis
- reductive amination
ASJC Scopus subject areas
- Catalysis
- General Chemistry