DNA-catalyzed reductive amination

On Yi Wong; Amanda E. Mulcrone; Scott K. Silverman

doi:10.1002/anie.201104976

DNA-catalyzed reductive amination

On Yi Wong, Amanda E. Mulcrone, Scott K. Silverman

Chemistry

Research output: Contribution to journal › Article

Abstract

A new reaction for DNA: DNA is shown to catalyze Ni²⁺-dependent reductive amination involving the N²-amine of a guanosine nucleobase (see picture). This finding expands the repertoire of nucleic acid catalysis to include reductive amination, an important natural biosynthetic reaction that has practical synthetic utility.

Original language	English (US)
Pages (from-to)	11679-11684
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	49
DOIs	https://doi.org/10.1002/anie.201104976
State	Published - Dec 2 2011

Keywords

DNA
deoxyribozymes
enzyme catalysis
reductive amination

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.201104976

Fingerprint Dive into the research topics of 'DNA-catalyzed reductive amination'. Together they form a unique fingerprint.

Cite this

Wong, O. Y., Mulcrone, A. E., & Silverman, S. K. (2011). DNA-catalyzed reductive amination. Angewandte Chemie - International Edition, 50(49), 11679-11684. https://doi.org/10.1002/anie.201104976

@article{0612ccdca6684fc6953f1e5d928ccd45,

title = "DNA-catalyzed reductive amination",

abstract = "A new reaction for DNA: DNA is shown to catalyze Ni2+-dependent reductive amination involving the N2-amine of a guanosine nucleobase (see picture). This finding expands the repertoire of nucleic acid catalysis to include reductive amination, an important natural biosynthetic reaction that has practical synthetic utility.",

keywords = "DNA, deoxyribozymes, enzyme catalysis, reductive amination",

author = "Wong, {On Yi} and Mulcrone, {Amanda E.} and Silverman, {Scott K.}",

year = "2011",

month = dec,

day = "2",

doi = "10.1002/anie.201104976",

language = "English (US)",

volume = "50",

pages = "11679--11684",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "49",

}

TY - JOUR

T1 - DNA-catalyzed reductive amination

AU - Wong, On Yi

AU - Mulcrone, Amanda E.

AU - Silverman, Scott K.

PY - 2011/12/2

Y1 - 2011/12/2

N2 - A new reaction for DNA: DNA is shown to catalyze Ni2+-dependent reductive amination involving the N2-amine of a guanosine nucleobase (see picture). This finding expands the repertoire of nucleic acid catalysis to include reductive amination, an important natural biosynthetic reaction that has practical synthetic utility.

AB - A new reaction for DNA: DNA is shown to catalyze Ni2+-dependent reductive amination involving the N2-amine of a guanosine nucleobase (see picture). This finding expands the repertoire of nucleic acid catalysis to include reductive amination, an important natural biosynthetic reaction that has practical synthetic utility.

KW - DNA

KW - deoxyribozymes

KW - enzyme catalysis

KW - reductive amination

UR - http://www.scopus.com/inward/record.url?scp=82455205713&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82455205713&partnerID=8YFLogxK

U2 - 10.1002/anie.201104976

DO - 10.1002/anie.201104976

M3 - Article

C2 - 21994131

AN - SCOPUS:82455205713

VL - 50

SP - 11679

EP - 11684

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 49

ER -