DNA-catalyzed reductive amination

On Yi Wong, Amanda E. Mulcrone, Scott K Silverman

Research output: Contribution to journal › Article

Abstract

A new reaction for DNA: DNA is shown to catalyze Ni2+-dependent reductive amination involving the N2-amine of a guanosine nucleobase (see picture). This finding expands the repertoire of nucleic acid catalysis to include reductive amination, an important natural biosynthetic reaction that has practical synthetic utility.

Original languageEnglish (US)
Pages (from-to)11679-11684
Number of pages6
JournalAngewandte Chemie - International Edition
Volume50
Issue number49
DOIs
StatePublished - Dec 2 2011

Fingerprint

Amination
DNA
Guanosine
Nucleic acids
Nucleic Acids
Catalysis
Amines

Keywords

  • DNA
  • deoxyribozymes
  • enzyme catalysis
  • reductive amination

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

DNA-catalyzed reductive amination. / Wong, On Yi; Mulcrone, Amanda E.; Silverman, Scott K.

In: Angewandte Chemie - International Edition, Vol. 50, No. 49, 02.12.2011, p. 11679-11684.

Research output: Contribution to journal › Article

Wong, OY, Mulcrone, AE & Silverman, SK 2011, 'DNA-catalyzed reductive amination', Angewandte Chemie - International Edition, vol. 50, no. 49, pp. 11679-11684. https://doi.org/10.1002/anie.201104976
Wong OY, Mulcrone AE, Silverman SK. DNA-catalyzed reductive amination. Angewandte Chemie - International Edition. 2011 Dec 2;50(49):11679-11684. https://doi.org/10.1002/anie.201104976
Wong, On Yi ; Mulcrone, Amanda E. ; Silverman, Scott K. / DNA-catalyzed reductive amination. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 49. pp. 11679-11684.
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