DNA-catalyzed reductive amination

On Yi Wong; Amanda E. Mulcrone; Scott K. Silverman

doi:10.1002/anie.201104976

DNA-catalyzed reductive amination

On Yi Wong, Amanda E. Mulcrone, Scott K. Silverman

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A new reaction for DNA: DNA is shown to catalyze Ni²⁺-dependent reductive amination involving the N²-amine of a guanosine nucleobase (see picture). This finding expands the repertoire of nucleic acid catalysis to include reductive amination, an important natural biosynthetic reaction that has practical synthetic utility.

Original language	English (US)
Pages (from-to)	11679-11684
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	49
DOIs	https://doi.org/10.1002/anie.201104976
State	Published - Dec 2 2011

Keywords

DNA
deoxyribozymes
enzyme catalysis
reductive amination

ASJC Scopus subject areas

Catalysis
General Chemistry

Online availability

10.1002/anie.201104976

Library availability

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DNA-catalyzed reductive amination

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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