DNA-catalyzed reductive amination

On Yi Wong, Amanda E. Mulcrone, Scott K Silverman

Research output: Contribution to journalArticle

Abstract

A new reaction for DNA: DNA is shown to catalyze Ni2+-dependent reductive amination involving the N2-amine of a guanosine nucleobase (see picture). This finding expands the repertoire of nucleic acid catalysis to include reductive amination, an important natural biosynthetic reaction that has practical synthetic utility.

Original languageEnglish (US)
Pages (from-to)11679-11684
Number of pages6
JournalAngewandte Chemie - International Edition
Volume50
Issue number49
DOIs
StatePublished - Dec 2 2011

Fingerprint

Amination
DNA
Guanosine
Nucleic acids
Nucleic Acids
Catalysis
Amines

Keywords

  • DNA
  • deoxyribozymes
  • enzyme catalysis
  • reductive amination

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

DNA-catalyzed reductive amination. / Wong, On Yi; Mulcrone, Amanda E.; Silverman, Scott K.

In: Angewandte Chemie - International Edition, Vol. 50, No. 49, 02.12.2011, p. 11679-11684.

Research output: Contribution to journalArticle

Wong, On Yi ; Mulcrone, Amanda E. ; Silverman, Scott K. / DNA-catalyzed reductive amination. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 49. pp. 11679-11684.
@article{0612ccdca6684fc6953f1e5d928ccd45,
title = "DNA-catalyzed reductive amination",
abstract = "A new reaction for DNA: DNA is shown to catalyze Ni2+-dependent reductive amination involving the N2-amine of a guanosine nucleobase (see picture). This finding expands the repertoire of nucleic acid catalysis to include reductive amination, an important natural biosynthetic reaction that has practical synthetic utility.",
keywords = "DNA, deoxyribozymes, enzyme catalysis, reductive amination",
author = "Wong, {On Yi} and Mulcrone, {Amanda E.} and Silverman, {Scott K}",
year = "2011",
month = "12",
day = "2",
doi = "10.1002/anie.201104976",
language = "English (US)",
volume = "50",
pages = "11679--11684",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "49",

}

TY - JOUR

T1 - DNA-catalyzed reductive amination

AU - Wong, On Yi

AU - Mulcrone, Amanda E.

AU - Silverman, Scott K

PY - 2011/12/2

Y1 - 2011/12/2

N2 - A new reaction for DNA: DNA is shown to catalyze Ni2+-dependent reductive amination involving the N2-amine of a guanosine nucleobase (see picture). This finding expands the repertoire of nucleic acid catalysis to include reductive amination, an important natural biosynthetic reaction that has practical synthetic utility.

AB - A new reaction for DNA: DNA is shown to catalyze Ni2+-dependent reductive amination involving the N2-amine of a guanosine nucleobase (see picture). This finding expands the repertoire of nucleic acid catalysis to include reductive amination, an important natural biosynthetic reaction that has practical synthetic utility.

KW - DNA

KW - deoxyribozymes

KW - enzyme catalysis

KW - reductive amination

UR - http://www.scopus.com/inward/record.url?scp=82455205713&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82455205713&partnerID=8YFLogxK

U2 - 10.1002/anie.201104976

DO - 10.1002/anie.201104976

M3 - Article

VL - 50

SP - 11679

EP - 11684

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 49

ER -