DNA-catalyzed glycosylation using aryl glycoside donors

Anthony R. Hesser; Benjamin M. Brandsen; Shannon M. Walsh; Puzhou Wang; Scott K. Silverman

doi:10.1039/c6cc04329a

DNA-catalyzed glycosylation using aryl glycoside donors

Anthony R. Hesser, Benjamin M. Brandsen, Shannon M. Walsh, Puzhou Wang, Scott K. Silverman

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

We report the identification by in vitro selection of Zn²⁺/Mn²⁺-dependent deoxyribozymes that glycosylate the 3′-OH of a DNA oligonucleotide. Both β and α anomers of aryl glycosides can be used as the glycosyl donors. Individual deoxyribozymes are each specific for a particular donor anomer.

Original language	English (US)
Pages (from-to)	9259-9262
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	59
DOIs	https://doi.org/10.1039/c6cc04329a
State	Published - 2016

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c6cc04329a

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title = "DNA-catalyzed glycosylation using aryl glycoside donors",

abstract = "We report the identification by in vitro selection of Zn2+/Mn2+-dependent deoxyribozymes that glycosylate the 3′-OH of a DNA oligonucleotide. Both β and α anomers of aryl glycosides can be used as the glycosyl donors. Individual deoxyribozymes are each specific for a particular donor anomer.",

author = "Hesser, {Anthony R.} and Brandsen, {Benjamin M.} and Walsh, {Shannon M.} and Puzhou Wang and Silverman, {Scott K.}",

note = "Funding Information: This work was supported by a grant to S. K. S. from the National Institutes of Health (R01GM065966). B. M. B. was partially supported by NIH T32GM070421. S. M. W. was partially supported by an NIH predoctoral fellowship (F31GM115147). Mass spectrometry was performed at the UIUC School of Chemical Sciences Mass Spectrometry Laboratory on an instrument purchased with support from NIH grant S10RR027109A. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

doi = "10.1039/c6cc04329a",

language = "English (US)",

volume = "52",

pages = "9259--9262",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - DNA-catalyzed glycosylation using aryl glycoside donors

AU - Hesser, Anthony R.

AU - Brandsen, Benjamin M.

AU - Walsh, Shannon M.

AU - Wang, Puzhou

AU - Silverman, Scott K.

N1 - Funding Information: This work was supported by a grant to S. K. S. from the National Institutes of Health (R01GM065966). B. M. B. was partially supported by NIH T32GM070421. S. M. W. was partially supported by an NIH predoctoral fellowship (F31GM115147). Mass spectrometry was performed at the UIUC School of Chemical Sciences Mass Spectrometry Laboratory on an instrument purchased with support from NIH grant S10RR027109A. Publisher Copyright: © The Royal Society of Chemistry 2016.

PY - 2016

Y1 - 2016

N2 - We report the identification by in vitro selection of Zn2+/Mn2+-dependent deoxyribozymes that glycosylate the 3′-OH of a DNA oligonucleotide. Both β and α anomers of aryl glycosides can be used as the glycosyl donors. Individual deoxyribozymes are each specific for a particular donor anomer.

AB - We report the identification by in vitro selection of Zn2+/Mn2+-dependent deoxyribozymes that glycosylate the 3′-OH of a DNA oligonucleotide. Both β and α anomers of aryl glycosides can be used as the glycosyl donors. Individual deoxyribozymes are each specific for a particular donor anomer.

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DO - 10.1039/c6cc04329a

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JO - Chemical Communications

JF - Chemical Communications

IS - 59

ER -

DNA-catalyzed glycosylation using aryl glycoside donors

Abstract

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