(Chemical Equation Presented) Joining amino acids and nucleotides: A deoxyribozyme catalyzes the nucleophilic attack of a tyrosine (Tyr) side chain on a 5′-triphosphate RNA, efficiently forming a Tyr-RNA nucleopeptide linkage (see picture). Thus, the scope of known DNA catalysis is further expanded beyond reactions of oligonucleotide functional groups.
|Original language||English (US)|
|Number of pages||5|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Feb 15 2008|
- Amino acids
- In vitro selection
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