DNA-catalyzed formation of nucleopeptide linkages

P. I. Pradeepkumar, Claudia Höbartner, Dana A. Baum, Scott K. Silverman

Research output: Contribution to journalArticlepeer-review


(Chemical Equation Presented) Joining amino acids and nucleotides: A deoxyribozyme catalyzes the nucleophilic attack of a tyrosine (Tyr) side chain on a 5′-triphosphate RNA, efficiently forming a Tyr-RNA nucleopeptide linkage (see picture). Thus, the scope of known DNA catalysis is further expanded beyond reactions of oligonucleotide functional groups.

Original languageEnglish (US)
Pages (from-to)1753-1757
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number9
StatePublished - Feb 15 2008


  • Amino acids
  • DNA
  • Deoxyribozymes
  • In vitro selection
  • Nucleopeptides

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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