We provide an overview of current approaches to DNA-based storage system design and of accompanying synthesis, sequencing and editing methods. We also introduce and analyze a suite of new constrained coding schemes for both archival and random access DNA storage channels. The analytic contribution of our work is the construction and design of sequences over discrete alphabets that avoid pre-specified address patterns, have balanced base content, and exhibit other relevant substring constraints. These schemes adapt the stored signals to the DNA medium and thereby reduce the inherent error-rate of the system.

Original languageEnglish (US)
Article number7423733
Pages (from-to)230-248
Number of pages19
JournalIEEE Transactions on Molecular, Biological, and Multi-Scale Communications
Issue number3
StatePublished - Sep 2015


  • Constrained and error-control coding
  • DNA synthesis and sequencing
  • DNAbased storage

ASJC Scopus subject areas

  • Bioengineering
  • Electrical and Electronic Engineering
  • Biotechnology
  • Computer Networks and Communications
  • Modeling and Simulation


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