Abstract
We provide an overview of current approaches to DNA-based storage system design and of accompanying synthesis, sequencing and editing methods. We also introduce and analyze a suite of new constrained coding schemes for both archival and random access DNA storage channels. The analytic contribution of our work is the construction and design of sequences over discrete alphabets that avoid pre-specified address patterns, have balanced base content, and exhibit other relevant substring constraints. These schemes adapt the stored signals to the DNA medium and thereby reduce the inherent error-rate of the system.
| Original language | English (US) |
|---|---|
| Article number | 7423733 |
| Pages (from-to) | 230-248 |
| Number of pages | 19 |
| Journal | IEEE Transactions on Molecular, Biological, and Multi-Scale Communications |
| Volume | 1 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2015 |
Keywords
- Constrained and error-control coding
- DNA synthesis and sequencing
- DNAbased storage
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Modeling and Simulation
- Computer Networks and Communications
- Electrical and Electronic Engineering