TY - JOUR
T1 - DNA aptamer technology for personalized medicine
AU - Xing, Hang
AU - Hwang, Kevin
AU - Li, Ji
AU - Torabi, Seyed Fakhreddin
AU - Lu, Yi
N1 - Funding Information:
We thank the US National Institute of Health ( ES016865 ) and the National Science Foundation ( DMR-0117792 , CTS-0120978 and DMI-0328162 ) for financial support.
PY - 2014/5
Y1 - 2014/5
N2 - This review highlights recent progress in developing DNA aptamers for personalized medicine, with more focus on in vivo studies for potential clinical applications. Examples include design of aptamers in combination with DNA nanostructures, nanomaterials, or microfluidic devices as diagnostic probes or therapeutic agents for cancers and other diseases. The use of aptamers as targeting agents in drug delivery is also covered. The advantages and future directions of such DNA aptamer-based technology for the continued development of personalized medicine are discussed.
AB - This review highlights recent progress in developing DNA aptamers for personalized medicine, with more focus on in vivo studies for potential clinical applications. Examples include design of aptamers in combination with DNA nanostructures, nanomaterials, or microfluidic devices as diagnostic probes or therapeutic agents for cancers and other diseases. The use of aptamers as targeting agents in drug delivery is also covered. The advantages and future directions of such DNA aptamer-based technology for the continued development of personalized medicine are discussed.
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U2 - 10.1016/j.coche.2014.01.007
DO - 10.1016/j.coche.2014.01.007
M3 - Review article
C2 - 24791224
AN - SCOPUS:84894284249
SN - 2211-3398
VL - 4
SP - 79
EP - 87
JO - Current Opinion in Chemical Engineering
JF - Current Opinion in Chemical Engineering
ER -