DMD-based spatially Fourier-encoded photoacoustic microscopy

Jinyang Liang, Liang Gao, Chiye Li, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present spatially Fourier-encoded photoacoustic microscopy using a digital micromirror device (DMD). The spatial fluence distribution of laser pulses is Fourier-encoded by the DMD, and a series of such encoded photoacoustic (PA) measurements enables decoding of the spatial distribution of optical absorption. By imaging a chromium target, we demonstrated the throughput and Fellgett advantages, which increased the PA signal-to-noise ratio (SNR) compared to raster scanning. The system was used to image two biological targets, a monolayer of red blood cells, and melanoma cells. The enhanced SNR benefited PA images by increasing the image's contrast-to-noise ratio and target identifiability.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2015
EditorsAlexander A. Oraevsky, Lihong V. Wang
PublisherSPIE
ISBN (Electronic)9781628414134
DOIs
StatePublished - Jan 1 2015
EventPhotons Plus Ultrasound: Imaging and Sensing 2015 - San Francisco, United States
Duration: Feb 8 2015Feb 10 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9323
ISSN (Print)1605-7422

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2015
CountryUnited States
CitySan Francisco
Period2/8/152/10/15

Keywords

  • Medical and biological imaging
  • Microscopy
  • Photoacoustic imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Liang, J., Gao, L., Li, C., & Wang, L. V. (2015). DMD-based spatially Fourier-encoded photoacoustic microscopy. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2015 [932324] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9323). SPIE. https://doi.org/10.1117/12.2076783