Diversities and similarities in P450 systems: An introduction

Research output: Contribution to journalArticle

Abstract

Looking across the tree of life, it is amazing that one finds cytochrome P450s represented in all life forms. Interestingly, common to these various life forms is a bipartite functionality. One major function of these monooxygenases is in xenobiotic metabolism and detoxification. Here, one finds the use of these monooxygenases in reactions ranging from the metabolism of pharmaceuticals in humans [33,179] to the removal of toxic substrances in insects and plants. A second major role in all life forms finds the P450s functioning in the biosynthesis of hormones and signaling molecules, again providing critical functions in mammals, insects and plants. It is clear that, despite their many differences, their similarities and existing technologies available for transferring genes from organism to the next are now allowing researchers with clear insight into the machinations of these enzymes to engineer P450s for many biotechnological applications. As summarized by Bernhardt [180], recombinant P450s have already been used for improving production of pharmaceuticals in bacterial systems and enhancing synthetic processes in plants with many remaining to be tested. Looking ahead in this ever-expanding field of research is exciting with work on P450 diversity providing the tools for many future biotechnological applications.

Original languageEnglish (US)
Pages (from-to)1-26
Number of pages26
JournalMetal Ions in Life Sciences
Volume3
StatePublished - Dec 1 2007

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Mixed Function Oxygenases
Metabolism
Detoxification
Mammals
Poisons
Biosynthesis
Xenobiotics
Cytochromes
Pharmaceutical Preparations
Insects
Genes
Hormones
Engineers
Molecules
Enzymes
Research Personnel
Technology
Research
isofenphos

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Diversities and similarities in P450 systems : An introduction. / Schuler, Mary A; Sligar, Stephen.

In: Metal Ions in Life Sciences, Vol. 3, 01.12.2007, p. 1-26.

Research output: Contribution to journalArticle

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