Diverse evolutionary origins and mechanisms of lens regeneration

Jonathan Joseph Henry, Paul W. Hamilton

Research output: Contribution to journalReview article

Abstract

In this review, we compare and contrast the three different forms of vertebrate lens regeneration: Wolffian lens regeneration, cornea-lens regeneration, and lens regeneration from lens epithelial cells. An examination of the diverse cellular origins of these lenses, their unique phylogenetic distribution, and the underlying molecular mechanisms, suggests that these different forms of lens regeneration evolved independently and utilize neither conserved nor convergent mechanisms to regulate these processes.

Original languageEnglish (US)
Pages (from-to)1563-1575
Number of pages13
JournalMolecular biology and evolution
Volume35
Issue number7
DOIs
StatePublished - Jan 1 2018

Fingerprint

Lens
Lenses
Regeneration
regeneration
vertebrate
cornea
phylogenetics
Cornea
Vertebrates
epithelial cells
Epithelial Cells
vertebrates
phylogeny

Keywords

  • Evolution
  • Lens regeneration
  • Signaling pathways
  • Vertebrates

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

Diverse evolutionary origins and mechanisms of lens regeneration. / Henry, Jonathan Joseph; Hamilton, Paul W.

In: Molecular biology and evolution, Vol. 35, No. 7, 01.01.2018, p. 1563-1575.

Research output: Contribution to journalReview article

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