Diverse evolutionary origins and mechanisms of lens regeneration

Jonathan J. Henry, Paul W. Hamilton

Research output: Contribution to journalReview article

Abstract

In this review, we compare and contrast the three different forms of vertebrate lens regeneration: Wolffian lens regeneration, cornea-lens regeneration, and lens regeneration from lens epithelial cells. An examination of the diverse cellular origins of these lenses, their unique phylogenetic distribution, and the underlying molecular mechanisms, suggests that these different forms of lens regeneration evolved independently and utilize neither conserved nor convergent mechanisms to regulate these processes.

Original languageEnglish (US)
Pages (from-to)1563-1575
Number of pages13
JournalMolecular biology and evolution
Volume35
Issue number7
DOIs
StatePublished - 2018

Keywords

  • Evolution
  • Lens regeneration
  • Signaling pathways
  • Vertebrates

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'Diverse evolutionary origins and mechanisms of lens regeneration'. Together they form a unique fingerprint.

  • Cite this