Diverse evolutionary origins and mechanisms of lens regeneration

Jonathan J. Henry, Paul W. Hamilton

Research output: Contribution to journalReview articlepeer-review


In this review, we compare and contrast the three different forms of vertebrate lens regeneration: Wolffian lens regeneration, cornea-lens regeneration, and lens regeneration from lens epithelial cells. An examination of the diverse cellular origins of these lenses, their unique phylogenetic distribution, and the underlying molecular mechanisms, suggests that these different forms of lens regeneration evolved independently and utilize neither conserved nor convergent mechanisms to regulate these processes.

Original languageEnglish (US)
Pages (from-to)1563-1575
Number of pages13
JournalMolecular biology and evolution
Issue number7
StatePublished - Jul 1 2018


  • Evolution
  • Lens regeneration
  • Signaling pathways
  • Vertebrates

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics


Dive into the research topics of 'Diverse evolutionary origins and mechanisms of lens regeneration'. Together they form a unique fingerprint.

Cite this