Diurnal rhythm of cytoplasmic estrogen receptors in the rat brain in the absence of circulating estrogens

Edward J. Roy, Marlene A. Wilson

Research output: Contribution to journalArticle

Abstract

The concentration of cytoplasmic estrogen receptors in the brain of ovariectomized female rats varies during the light-dark cycle. There is no variation in the affinity of the receptors for estradiol, and the rhythm is not due to estrogens from nonovarian sources. Pentobarbital reverses the reduction of receptors that occurs in the dark, and melatonin injection in the light partially mimics the action of darkness in reducing receptor levels. The factors that cause this rhythm in brain estrogen receptors may be one means by which light affects reproductive function.

Original languageEnglish (US)
Pages (from-to)1527-1529
Number of pages3
JournalScience
Volume213
Issue number4515
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Diurnal rhythm of cytoplasmic estrogen receptors in the rat brain in the absence of circulating estrogens'. Together they form a unique fingerprint.

  • Cite this