Abstract
The concentration of cytoplasmic estrogen receptors in the brain of ovariectomized female rats varies during the light-dark cycle. There is no variation in the affinity of the receptors for estradiol, and the rhythm is not due to estrogens from nonovarian sources. Pentobarbital reverses the reduction of receptors that occurs in the dark, and melatonin injection in the light partially mimics the action of darkness in reducing receptor levels. The factors that cause this rhythm in brain estrogen receptors may be one means by which light affects reproductive function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1527-1529 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 213 |
| Issue number | 4515 |
| State | Published - Jan 1 1981 |
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ASJC Scopus subject areas
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Cite this
Diurnal rhythm of cytoplasmic estrogen receptors in the rat brain in the absence of circulating estrogens. / Roy, Edward J; Wilson, Marlene A.
In: Science, Vol. 213, No. 4515, 01.01.1981, p. 1527-1529.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diurnal rhythm of cytoplasmic estrogen receptors in the rat brain in the absence of circulating estrogens
AU - Roy, Edward J
AU - Wilson, Marlene A.
PY - 1981/1/1
Y1 - 1981/1/1
N2 - The concentration of cytoplasmic estrogen receptors in the brain of ovariectomized female rats varies during the light-dark cycle. There is no variation in the affinity of the receptors for estradiol, and the rhythm is not due to estrogens from nonovarian sources. Pentobarbital reverses the reduction of receptors that occurs in the dark, and melatonin injection in the light partially mimics the action of darkness in reducing receptor levels. The factors that cause this rhythm in brain estrogen receptors may be one means by which light affects reproductive function.
AB - The concentration of cytoplasmic estrogen receptors in the brain of ovariectomized female rats varies during the light-dark cycle. There is no variation in the affinity of the receptors for estradiol, and the rhythm is not due to estrogens from nonovarian sources. Pentobarbital reverses the reduction of receptors that occurs in the dark, and melatonin injection in the light partially mimics the action of darkness in reducing receptor levels. The factors that cause this rhythm in brain estrogen receptors may be one means by which light affects reproductive function.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019830728&partnerID=8YFLogxK
M3 - Article
C2 - 7197053
AN - SCOPUS:0019830728
VL - 213
SP - 1527
EP - 1529
JO - Science
JF - Science
SN - 0036-8075
IS - 4515
ER -