Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry

Keyphrases

• Dehydration 100%
• Synthetase 100%
• Lantibiotics 100%
• High-resolution Tandem Mass Spectrometry 100%
• Lanthionine 66%
• Michael Addition 33%
• Alkylation 33%
• Regioselectivity 33%
• Cysteine Residues 33%
• In Vitro Activity 33%
• Substrate Binding 33%
• Mass Spectra 33%
• Electrospray 33%
• Free Cysteine 33%
• Cyclization 33%
• Fourier Transform Mass Spectrometry 33%
• Threonine 33%
• Bifunctional Enzyme 33%
• Ring Formation 33%
• Dehydroamino Acids 33%
• Substrate Peptide 33%
• Cyclization Processes 33%
• Cyclization Activity 33%
• Distributive Mechanism 33%

Biochemistry, Genetics and Molecular Biology

• Tandem Mass Spectrometry 100%
• Lantibiotic 100%
• Cysteine 66%
• Lanthionine 66%
• N-Terminus 33%
• Mass Spectrometry 33%
• Enzyme 33%
• Electrospray Ionization 33%
• C-Terminus 33%
• Regioselectivity 33%
• Alkylation 33%
• Serine 33%
• Threonine 33%

Chemistry

• Tandem Mass Spectrometry 100%
• Lantibiotic 100%
• Lanthionine 66%
• Cysteine 66%
• Regioselectivity 33%
• Electrospray 33%
• FT/ICR Mass Spectrometry 33%
• Serine Residue 33%
• Michael Reaction 33%
• Ring Formation 33%
• Dehydroamino Acid 33%
• Threonine Residue 33%
• Alkylation 33%