Distribution of porcine CD4/CD8 double-positive T lymphocytes in mucosa-associated lymphoid tissues

Research output: Contribution to journalArticle

Abstract

The present study describes the distribution of CD4/CD8 double-positive (DP) T cells in lymph nodes and mucosa-associated lymphoid tissues of pigs at 6-7 months of age. Proportions of lymphocytes isolated from peripheral, bronchial and mesenteric lymph nodes expressing CD4 and/ or CD8 molecules were similar and ranged from 10-13% CD4/CD8 DP cells, 25-27% CD4 single-positive (SP) cells, and 27-32% CD8 SP cells. Mucosa-associated lymphoid tissues had significantly smaller proportions of CD4+ and/or CD8+ T cells than lymph nodes and CD4/ CD8 DP cells accounted for a larger proportion of the total CD4+ lymphocytes than in lymph nodes. Compared to the lymph nodes, the predominant CD4+ and/or CD8+ T-cell subset in tonsils was the CD4/CD8 DP population (18%), because of both a higher proportion of these cells and a lower proportion of CD4 SP (12%) and CD8 SP (14%) lymphocyte subsets. Jejunal Peyer's patches were comprised of 12% CD4 SP, 28% CD8 SP and 10% CD4/CD8 DP lymphocytes. In contrast, the mid-section of the continuous Peyer's patch in the ileum contained 7% CD4 SP, 8% CD8 SP and 4% CD4/CD8 DP lymphocytes. The distribution of T lymphocytes in porcine mucosal lymphoid aggregates agrees with the reported correlation between high and low rates of lymphocyte entry into these tissues and the abundance or scarcity of T cells, respectively. Defining the role of CD4/CD8 DP lymphocytes and their unique distribution in mucosa-associated lymphoid tissues in the pig may reveal novel T-cell-mediated regulatory pathways.

Original languageEnglish (US)
Pages (from-to)493-499
Number of pages7
JournalImmunology
Volume87
Issue number3
DOIs
StatePublished - Jan 1 1996

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CD8-Positive T-Lymphocytes
Lymphoid Tissue
Mucous Membrane
Swine
Lymph Nodes
T-Lymphocytes
Peyer's Patches
Lymphocytes
Palatine Tonsil
Lymphocyte Subsets
T-Lymphocyte Subsets
Regulatory T-Lymphocytes
Ileum
Population

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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Distribution of porcine CD4/CD8 double-positive T lymphocytes in mucosa-associated lymphoid tissues. / Zuckermann, Federico A; Gaskins, H Rex.

In: Immunology, Vol. 87, No. 3, 01.01.1996, p. 493-499.

Research output: Contribution to journalArticle

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