Distinct molecular targets for the central respiratory and cardiac actions of etomidate and propofol

Anja Zeller, Margarete Arras, Rachel Jurd, Uwe Rudolph

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the involvement of β3-containing GABAA receptors in the respiratory and cardiovascular actions of etomidate and propofol using β3(N265M) knock-in mice. While the respiratory depressant action of etomidate and propofol was almost absent in β3(N265M) mice, the cardiac depressant action was still present.

Original languageEnglish (US)
Pages (from-to)253-255
Number of pages3
JournalInternational Congress Series
Volume1283
DOIs
StatePublished - Nov 2005
Externally publishedYes

Keywords

  • Anesthesia
  • Animal model
  • GABA receptor
  • Respiratory depression

ASJC Scopus subject areas

  • Medicine(all)

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