Abstract

Hydrogels have a large number of applications in microelectromechanical systems (MEMS) technology as sensors and actuators. In this paper we investigate the use of responsive micro-sized hydrogels as transducers of biochemical signals. Hydrogels, crosslinked via disulfide bonds, when immersed in a solution containing a disulfide reducing agent can dissolve as the covalent cross-links are cleaved by the reducing agent and thereby indicate the presence of the cleaving agent. As a result, this phenomenon leads to the transduction of chemical signal to visual signal. The mechanism of the hydrogel dissolution process has been studied in detail and a mathematical model has been developed. From the vanishing time of the dissolvable hydrogel, a significant amount of information about the surrounding bath solution can be obtained.

Original languageEnglish (US)
Title of host publicationTRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages734-737
Number of pages4
ISBN (Electronic)0780377311, 9780780377318
DOIs
StatePublished - Jan 1 2003
Event12th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2003 - Digest of Technical Papers - Boston, United States
Duration: Jun 8 2003Jun 12 2003

Publication series

NameTRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers
Volume1

Other

Other12th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2003 - Digest of Technical Papers
CountryUnited States
CityBoston
Period6/8/036/12/03

Fingerprint

Hydrogels
Transducers
Reducing agents
MEMS
Dissolution
Actuators
Mathematical models
Sensors

Keywords

  • Actuators
  • Biological system modeling
  • Chemical sensors
  • Chemical technology
  • Chemical transducers
  • Mathematical model
  • Microelectromechanical systems
  • Micromechanical devices
  • Polymers
  • Sensor systems and applications

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Chatterjee, A. N., Moore, J. S., Beebe, D. J., & Aluru, N. R. (2003). Dissolvable hydrogels as transducers of bio-chemical signals: Models and simulations. In TRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers (pp. 734-737). [1215578] (TRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers; Vol. 1). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/SENSOR.2003.1215578

Dissolvable hydrogels as transducers of bio-chemical signals : Models and simulations. / Chatterjee, A. N.; Moore, J. S.; Beebe, D. J.; Aluru, N. R.

TRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers. Institute of Electrical and Electronics Engineers Inc., 2003. p. 734-737 1215578 (TRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers; Vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chatterjee, AN, Moore, JS, Beebe, DJ & Aluru, NR 2003, Dissolvable hydrogels as transducers of bio-chemical signals: Models and simulations. in TRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers., 1215578, TRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers, vol. 1, Institute of Electrical and Electronics Engineers Inc., pp. 734-737, 12th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2003 - Digest of Technical Papers, Boston, United States, 6/8/03. https://doi.org/10.1109/SENSOR.2003.1215578
Chatterjee AN, Moore JS, Beebe DJ, Aluru NR. Dissolvable hydrogels as transducers of bio-chemical signals: Models and simulations. In TRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers. Institute of Electrical and Electronics Engineers Inc. 2003. p. 734-737. 1215578. (TRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers). https://doi.org/10.1109/SENSOR.2003.1215578
Chatterjee, A. N. ; Moore, J. S. ; Beebe, D. J. ; Aluru, N. R. / Dissolvable hydrogels as transducers of bio-chemical signals : Models and simulations. TRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers. Institute of Electrical and Electronics Engineers Inc., 2003. pp. 734-737 (TRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers).
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