Dissecting the influences of combinatorial microenvironments on hepatic stellate cell phenotype and behavior

I. Jain, A. Brougham-Cook, D. Kukla, S. Khetani, G. Underhill

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Non-alcoholic steatohepatitis (NASH) is an emerging epidemic of liver disease and the basis for a rising incidence of fibrosis and hepatocellular carcinoma1. Recently, hepatic stellate cells (HSCs) have been identified as the primary drivers of liver fibrosis2. Changes in the composition of the liver microenvironment during fibrosis results in a complex crosstalk of extracellular cues that promotes the activation, or differentiation, of HSCs from a quiescent, vitamin A storing phenotype to a myofibroblastic phenotype. While these chemo-mechanical signaling processes are well understood in rodent HSC models, very little is known about extracellular influences on HSC activation in humans. Here, we have utilized a high-throughput cellular microarray platform to dissect the cooperative influences of defined combinations of extracellular matrix (ECM) proteins and substrate stiffnesses on human HSC phenotype and behavior3.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages395
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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