Turns and bends, such as an L-turn or a U-turn, in micro and nano-fluidic channels can induce significant dispersion leading to a low efficiency electrophoretic separation process. It has been shown that turn-induced dispersion can be lowered by optimizing the geometry of the turns. In this paper, we propose a new approach for controlling turn-induced dispersion in nano-fluidic channels. The approach is based on the idea of locally controlling the ζ-potential at turns and bends. An optimization algorithm was developed to search for the optimal configuration of the ζ-potential near turns. Results for an L-turn and a U-turn show that the dispersion can be lowered significantly by a localized ζ-potential variation near the turn.

Original languageEnglish (US)
Pages (from-to)268-274
Number of pages7
JournalSensors and Actuators, A: Physical
Issue number3
StatePublished - May 15 2003


  • ζ-potential
  • Dispersion control
  • Nano-fluidic channels
  • Optimization

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Instrumentation


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