Discovery of a novel putative atypical porcine pestivirus in pigs in the USA

Ben M. Hause, Emily A. Collin, Lalitha Peddireddi, Fangfeng Yuan, Zhenhai Chen, Richard A. Hesse, Phillip C. Gauger, Travis Clement, Ying Fang, Gary Anderson

Research output: Contribution to journalArticlepeer-review


Pestiviruses are some of the most significant pathogens affecting ruminants and swine, Here, we assembled a 11 276 bp contig encoding a predicted 3635 aa polyprotein from porcine serum with 68 % pairwise identity to that of a recently partially characterized Rhinolophus affinis pestivirus (RaPV) and approximately 25–28 % pairwise identity to those of other pestiviruses, The virus was provisionally named atypical porcine pestivirus (APPV), Metagenomic sequencing of 182 serum samples identified four additional APPV-positive samples, Positive samples originated from five states and ELISAs using recombinant APPV Erns found cross-reactive antibodies in 94% of a collection of porcine serum samples, suggesting widespread distribution of APPV in the US swine herd, The molecular and serological results suggest that APPV is a novel, highly divergent porcine pestivirus widely distributed in US pigs.

Original languageEnglish (US)
Pages (from-to)2994-2998
Number of pages5
JournalJournal of General Virology
Issue number10
StatePublished - Oct 2015
Externally publishedYes

ASJC Scopus subject areas

  • Virology


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