Discovery and biosynthesis of phosphonate and phosphinate natural products

Spencer C. Peck, Jiangtao Gao, Wilfred Adrianus van der Donk

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The PC bonds in phosphonate and phosphinate natural products endow them with a high level of stability and the ability to mimic phosphate esters and carboxylates. As such, they have a diverse range of enzyme targets that act on substrates containing such functionalities. Recent years have seen a renewed interest in discovery efforts focused on this class of compounds as well as in understanding their biosynthetic pathways. This chapter focuses on current knowledge of these biosynthetic pathways as well as tools for phosphonate discovery.

Original languageEnglish (US)
Title of host publicationMethods in Enzymology
PublisherAcademic Press Inc.
Pages101-123
Number of pages23
DOIs
StatePublished - 2012

Publication series

NameMethods in Enzymology
Volume516
ISSN (Print)0076-6879
ISSN (Electronic)1557-7988

Fingerprint

Organophosphonates
Biosynthesis
Biosynthetic Pathways
Biological Products
Esters
Phosphates
Substrates
Enzymes

Keywords

  • APPA
  • Fosfomycin
  • Fosmidomycin
  • Glufosinate
  • Glyphosate
  • PEP mutase
  • Phosphinothricin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Peck, S. C., Gao, J., & van der Donk, W. A. (2012). Discovery and biosynthesis of phosphonate and phosphinate natural products. In Methods in Enzymology (pp. 101-123). (Methods in Enzymology; Vol. 516). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-394291-3.00029-0

Discovery and biosynthesis of phosphonate and phosphinate natural products. / Peck, Spencer C.; Gao, Jiangtao; van der Donk, Wilfred Adrianus.

Methods in Enzymology. Academic Press Inc., 2012. p. 101-123 (Methods in Enzymology; Vol. 516).

Research output: Chapter in Book/Report/Conference proceedingChapter

Peck, SC, Gao, J & van der Donk, WA 2012, Discovery and biosynthesis of phosphonate and phosphinate natural products. in Methods in Enzymology. Methods in Enzymology, vol. 516, Academic Press Inc., pp. 101-123. https://doi.org/10.1016/B978-0-12-394291-3.00029-0
Peck SC, Gao J, van der Donk WA. Discovery and biosynthesis of phosphonate and phosphinate natural products. In Methods in Enzymology. Academic Press Inc. 2012. p. 101-123. (Methods in Enzymology). https://doi.org/10.1016/B978-0-12-394291-3.00029-0
Peck, Spencer C. ; Gao, Jiangtao ; van der Donk, Wilfred Adrianus. / Discovery and biosynthesis of phosphonate and phosphinate natural products. Methods in Enzymology. Academic Press Inc., 2012. pp. 101-123 (Methods in Enzymology).
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