@inbook{68ed289ac3d940858b584ce996f67e05,
title = "Discovery and biosynthesis of phosphonate and phosphinate natural products",
abstract = "The PC bonds in phosphonate and phosphinate natural products endow them with a high level of stability and the ability to mimic phosphate esters and carboxylates. As such, they have a diverse range of enzyme targets that act on substrates containing such functionalities. Recent years have seen a renewed interest in discovery efforts focused on this class of compounds as well as in understanding their biosynthetic pathways. This chapter focuses on current knowledge of these biosynthetic pathways as well as tools for phosphonate discovery.",
keywords = "APPA, Fosfomycin, Fosmidomycin, Glufosinate, Glyphosate, PEP mutase, Phosphinothricin",
author = "Peck, {Spencer C.} and Jiangtao Gao and {Van Der Donk}, {Wilfred A.}",
note = "Funding Information: Our work on phosphonate biosynthesis is supported by the National Institutes of Health (GM077596 to W. A. v. d. D). S. C. P. is a trainee in the Chemistry–Biology Interface Training Program (TM32 GM070421). We thank our coworkers in the Metcalf and van der Donk laboratories for sharing their protocols and Xudong Guan for recording the HMBC spectra.",
year = "2012",
doi = "10.1016/B978-0-12-394291-3.00029-0",
language = "English (US)",
series = "Methods in Enzymology",
publisher = "Academic Press Inc.",
pages = "101--123",
booktitle = "Methods in Enzymology",
address = "United States",
}