Discovery and biosynthesis of phosphonate and phosphinate natural products

Spencer C. Peck, Jiangtao Gao, Wilfred A. Van Der Donk

Research output: Chapter in Book/Report/Conference proceedingChapter


The PC bonds in phosphonate and phosphinate natural products endow them with a high level of stability and the ability to mimic phosphate esters and carboxylates. As such, they have a diverse range of enzyme targets that act on substrates containing such functionalities. Recent years have seen a renewed interest in discovery efforts focused on this class of compounds as well as in understanding their biosynthetic pathways. This chapter focuses on current knowledge of these biosynthetic pathways as well as tools for phosphonate discovery.

Original languageEnglish (US)
Title of host publicationMethods in Enzymology
PublisherAcademic Press Inc.
Number of pages23
StatePublished - 2012

Publication series

NameMethods in Enzymology
ISSN (Print)0076-6879
ISSN (Electronic)1557-7988


  • APPA
  • Fosfomycin
  • Fosmidomycin
  • Glufosinate
  • Glyphosate
  • PEP mutase
  • Phosphinothricin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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