Directed Evolution of CRISPR-Cas9 Base Editors

Jackson Winter, Pablo Perez-Pinera

Research output: Contribution to journalShort surveypeer-review


A recent publication by Thuronyi et al. described a directed evolution system called phage-assisted continuous evolution (PACE) that was used to generate improved variants of CRISPR-Cas9 base editors. These evolved base editors overcome some of the inherent limitations of the technology such as sequence context preferences, restricted editing windows, and large construct sizes.

Original languageEnglish (US)
Pages (from-to)1151-1153
Number of pages3
JournalTrends in Biotechnology
Issue number11
StatePublished - Nov 2019

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology


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