Directed blood vessel growth using an angiogenic microfiber/microparticle composite patch

Ross J. Devolder, Harim Bae, Jonghwi Lee, Hyunjoon Kong

Research output: Contribution to journalArticle

Abstract

An angiogenic microfiber patch that releases angiogenic growth factors along aligned fibers and subsequently directs the spacing and orientation of mature and functional blood vessel formation is presented. The fiber patches are prepared by electrostatically binding electrosprayed vascular endothelial growth factor (VEGF)-encapsulating poly(lactide-co-glycolide) (PLGA) microparticles with electrospun poly(lactide) (PLA) microfibers.

Original languageEnglish (US)
Pages (from-to)3139-3143
Number of pages5
JournalAdvanced Materials
Volume23
Issue number28
DOIs
StatePublished - Jul 26 2011

Keywords

  • drug delivery
  • fibers
  • microstructures
  • polymeric materials
  • tissue engineering

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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