TY - JOUR
T1 - Direct and Divergent Solid-Phase Synthesis of Azobenzene and Spiropyran Derivatives
AU - Kollarigowda, Ravichandran H.
AU - Braun, Paul V.
N1 - Funding Information:
This research was supported by the Department of Defense/US Army W911NF-17-1-0351 through the Materials Research Laboratory at the University of Illinois. The authors thank to Ms. Chen Chen for helping with NMR analysis.
Publisher Copyright:
©
PY - 2021/3/19
Y1 - 2021/3/19
N2 - Here, we report a solid-phase approach to synthesize azobenzene and spiropyran derivatives. The divergent synthesis process requires no purification steps to obtain the desired product with a 28-55% yield, depending on the specific compound. For the spiropyran compounds, solid-phase resin cleavage is performed under mild conditions to minimize spiropyran ring opening. The solid-phase method enables the synthesis of a library of azobenzene and spiropyran derivatives without the need to develop purification strategies for each derivative.
AB - Here, we report a solid-phase approach to synthesize azobenzene and spiropyran derivatives. The divergent synthesis process requires no purification steps to obtain the desired product with a 28-55% yield, depending on the specific compound. For the spiropyran compounds, solid-phase resin cleavage is performed under mild conditions to minimize spiropyran ring opening. The solid-phase method enables the synthesis of a library of azobenzene and spiropyran derivatives without the need to develop purification strategies for each derivative.
UR - http://www.scopus.com/inward/record.url?scp=85103310317&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85103310317&partnerID=8YFLogxK
U2 - 10.1021/acs.joc.0c02375
DO - 10.1021/acs.joc.0c02375
M3 - Article
C2 - 33656880
AN - SCOPUS:85103310317
SN - 0022-3263
VL - 86
SP - 4391
EP - 4397
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 6
ER -