Direct and Divergent Solid-Phase Synthesis of Azobenzene and Spiropyran Derivatives

Ravichandran H. Kollarigowda, Paul V. Braun

Research output: Contribution to journalArticlepeer-review


Here, we report a solid-phase approach to synthesize azobenzene and spiropyran derivatives. The divergent synthesis process requires no purification steps to obtain the desired product with a 28-55% yield, depending on the specific compound. For the spiropyran compounds, solid-phase resin cleavage is performed under mild conditions to minimize spiropyran ring opening. The solid-phase method enables the synthesis of a library of azobenzene and spiropyran derivatives without the need to develop purification strategies for each derivative.

Original languageEnglish (US)
Pages (from-to)4391-4397
Number of pages7
JournalJournal of Organic Chemistry
Issue number6
StatePublished - Mar 19 2021

ASJC Scopus subject areas

  • Organic Chemistry


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