Digestive System

Research output: Chapter in Book/Report/Conference proceedingChapter


When considering the potential toxic activity of various agents on the gastrointestinal (GI) tract, a number of mechanisms are possible. For example, acute toxic effects may result from direct irritants (e.g., strong acids and bases), whereas chronic effects maybe manifested as increased muscular layer thickness from bulking agents. Delayed effects maybe expressed years after exposure to the initial ulcerogenic or carcinogenic agents. In addition to an array of tissue responses, the mechanistic relationships between functional abnormalities and morphological alterations can be complex. The focus of this chapter is to examine structural and functional components of the GI tract that are important in understanding mechanisms involved in the toxicologic pathology of this organ system. A major part of the chapter stresses basic mechanisms of toxicologic damage, and how the GI tract responds to toxicologic insult. Also discussed in brief are morphologic approaches that can be used to study selected pathologic mechanisms of toxicological significance.

Original languageEnglish (US)
Title of host publicationFundamentals of Toxicologic Pathology
EditorsMatthew A Wallig, Wanda M Haschek, Colin G Rousseaux, Brad Bolon
PublisherAcademic Press
Number of pages48
ISBN (Electronic)9780128098424
ISBN (Print)9780128098417
StatePublished - 2018


  • Acetylcholine
  • Arachidonic acid
  • Arsenic
  • Barrier function
  • Bile salts
  • Biotransformation
  • Cadmium
  • Cecum
  • Colon
  • Constipation
  • Crypts
  • Cyclooxygenase (COX)
  • Cytochrome P450 (CYP)
  • Diarrhea
  • Dioxins
  • Duodenum
  • Emesis
  • Enteric lymphoid system
  • Enteric nervous system
  • Enterocyte
  • Enterohepatic
  • Erosion
  • Esophagus
  • Ethanol
  • Forestomach
  • Fundus
  • Gastric glands
  • Gastrin
  • Glucuronidation
  • Glucuronide
  • Glucuronosyl transferase
  • Glutathione
  • Growth factor
  • Gut-associated lymphoid tissue (GALT)
  • Heavy metals
  • Helicobacter
  • Hypersensitivity
  • Hypoxia
  • Ileum
  • Jejunum
  • Large intestine
  • Malabsorption
  • Mercury
  • Microbiota
  • Microflora
  • Motility
  • Mucin
  • Mucosa
  • Mucosal barrier
  • Mucosal immunity
  • Mucus
  • Muscularis
  • NSAIDs
  • Proliferation
  • Pylorus
  • Radiomimetic agents
  • Regeneration
  • Small intestine
  • Stem cells
  • Steroids
  • Stomach
  • Sulfation
  • TCDD
  • TNF-α
  • Ulcer
  • Ulcerative
  • Ulcerogens
  • Vagus
  • Vomiting
  • β-catenin

ASJC Scopus subject areas

  • General Medicine


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