Diffusion tensor imaging of mouse brain stem and cervical spinal cord

Joong Hee Kim; Justin Haldar; Zhi Pei Liang; Sheng Kwei Song

doi:10.1016/j.jneumeth.2008.09.005

Diffusion tensor imaging of mouse brain stem and cervical spinal cord

Joong Hee Kim, Justin Haldar, Zhi Pei Liang, Sheng Kwei Song

Research output: Contribution to journal › Article › peer-review

Abstract

In vivo diffusion tensor imaging measurements of the mouse brain stem and cervical spinal cord are presented. Utilizing actively decoupled transmit/receive coils, high resolution diffusion images (117 μm × 59 μm × 500 μm) were acquired at 4.7 T within an hour. Both brain stem and cervical spine displayed clear gray-white matter contrast. The cervical spinal cord white matter showed similar tissue characteristics as seen in the thoracic cord. The coherent fiber orientation in the white matter was observed in both the brain stem and the cervical spinal cord. The results may serve as a reference for future inter-lab comparison in mouse brain stem and cervical spine diffusion measurements.

Original language	English (US)
Pages (from-to)	186-191
Number of pages	6
Journal	Journal of Neuroscience Methods
Volume	176
Issue number	2
DOIs	https://doi.org/10.1016/j.jneumeth.2008.09.005
State	Published - Jan 30 2009

Keywords

Axial and radial diffusivity
Brain stem
Cervical spinal cord
Diffusion anisotropy
Diffusion tensor imaging
Mice

ASJC Scopus subject areas

Neuroscience(all)

Online availability

10.1016/j.jneumeth.2008.09.005

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title = "Diffusion tensor imaging of mouse brain stem and cervical spinal cord",

abstract = "In vivo diffusion tensor imaging measurements of the mouse brain stem and cervical spinal cord are presented. Utilizing actively decoupled transmit/receive coils, high resolution diffusion images (117 μm × 59 μm × 500 μm) were acquired at 4.7 T within an hour. Both brain stem and cervical spine displayed clear gray-white matter contrast. The cervical spinal cord white matter showed similar tissue characteristics as seen in the thoracic cord. The coherent fiber orientation in the white matter was observed in both the brain stem and the cervical spinal cord. The results may serve as a reference for future inter-lab comparison in mouse brain stem and cervical spine diffusion measurements.",

keywords = "Axial and radial diffusivity, Brain stem, Cervical spinal cord, Diffusion anisotropy, Diffusion tensor imaging, Mice",

author = "Kim, {Joong Hee} and Justin Haldar and Liang, {Zhi Pei} and Song, {Sheng Kwei}",

note = "Funding Information: This study was supported in part by National Institute of Health NS047592, and the University of Missouri Spinal Cord Injuries Research Program.",

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AU - Kim, Joong Hee

AU - Haldar, Justin

AU - Liang, Zhi Pei

AU - Song, Sheng Kwei

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Y1 - 2009/1/30

N2 - In vivo diffusion tensor imaging measurements of the mouse brain stem and cervical spinal cord are presented. Utilizing actively decoupled transmit/receive coils, high resolution diffusion images (117 μm × 59 μm × 500 μm) were acquired at 4.7 T within an hour. Both brain stem and cervical spine displayed clear gray-white matter contrast. The cervical spinal cord white matter showed similar tissue characteristics as seen in the thoracic cord. The coherent fiber orientation in the white matter was observed in both the brain stem and the cervical spinal cord. The results may serve as a reference for future inter-lab comparison in mouse brain stem and cervical spine diffusion measurements.

AB - In vivo diffusion tensor imaging measurements of the mouse brain stem and cervical spinal cord are presented. Utilizing actively decoupled transmit/receive coils, high resolution diffusion images (117 μm × 59 μm × 500 μm) were acquired at 4.7 T within an hour. Both brain stem and cervical spine displayed clear gray-white matter contrast. The cervical spinal cord white matter showed similar tissue characteristics as seen in the thoracic cord. The coherent fiber orientation in the white matter was observed in both the brain stem and the cervical spinal cord. The results may serve as a reference for future inter-lab comparison in mouse brain stem and cervical spine diffusion measurements.

KW - Axial and radial diffusivity

KW - Brain stem

KW - Cervical spinal cord

KW - Diffusion anisotropy

KW - Diffusion tensor imaging

KW - Mice

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Diffusion tensor imaging of mouse brain stem and cervical spinal cord

Abstract

Keywords

ASJC Scopus subject areas

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