Diffuse interstitial pulmonary fibrosis. Pulmonary fibrosis in mice induced by treatment with butylated hydroxytoluene and oxygen

W. M. Haschek, A. R. Brody, A. J.P. Klein-Szanto, H. Witschi

Research output: Contribution to journalArticlepeer-review

Abstract

Young adult male BALB/c mice were intraperitoneally injected with 400 mg butylated hydroxytoluene/kg body weight and immediately placed in 70% oxygen for 6 days. An extensive interstitial pulmonary fibrosis developed 14 days after the beginning of the experiment. An increase in lung collagen was confirmed electron-microscopically. Comparison with human disease and usefulness of this animal model are discussed. (Nizze - Rostock)

Original languageEnglish (US)
Pages (from-to)333-335
Number of pages3
JournalAmerican Journal of Pathology
Volume105
Issue number3
StatePublished - Jan 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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