Diffraction phase microscopy: Principles and applications in materials and life sciences

Basanta Bhaduri, Chris Edwards, Hoa Pham, Renjie Zhou, Tan H. Nguyen, Lynford L Goddard, Gabriel Popescu

Research output: Contribution to journalArticle

Abstract

The main obstacle in retrieving quantitative phase with high sensitivity is posed by the phase noise due to mechanical vibrations and air fluctuations that typically affect any interferometric system. In this paper, we review diffraction phase microscopy (DPM), which is a common-path quantitative phase imaging (QPI) method that significantly alleviates the noise problem. DPM utilizes a compact Mach-Zehnder interferometer to combine several attributes of current QPI methods. This compact configuration inherently cancels out most mechanisms responsible for noise and is single-shot, meaning that the acquisition speed is limited only by the speed of the camera employed. This technique is also nondestructive and does not require staining or coating of the specimen. This unique collection of features enables the DPM system to accurately monitor the dynamics of various nanoscale phenomena in a wide variety of environments. The DPM system can operate in both transmission and reflection modes in order to accommodate both transparent and opaque samples, respectively. Thus, current applications of DPM include measuring the dynamics of biological samples, semiconductor wet etching and photochemical etching processes, surface wetting and evaporation of water droplets, self-assembly of nanotubes, expansion and deformation of materials, and semiconductor wafer defect detection. Finally, DPM with white light averages out much of the speckle background and also offers potential for spectroscopic measurements.

Original languageEnglish (US)
Pages (from-to)57-119
Number of pages63
JournalAdvances in Optics and Photonics
Volume6
Issue number1
DOIs
StatePublished - 2014

Fingerprint

life sciences
materials science
microscopy
diffraction
etching
Mach-Zehnder interferometers
staining
shot
wetting
self assembly
nanotubes
acquisition
cameras
evaporation
wafers
coatings
vibration
expansion
sensitivity
air

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Diffraction phase microscopy : Principles and applications in materials and life sciences. / Bhaduri, Basanta; Edwards, Chris; Pham, Hoa; Zhou, Renjie; Nguyen, Tan H.; Goddard, Lynford L; Popescu, Gabriel.

In: Advances in Optics and Photonics, Vol. 6, No. 1, 2014, p. 57-119.

Research output: Contribution to journalArticle

Bhaduri, Basanta ; Edwards, Chris ; Pham, Hoa ; Zhou, Renjie ; Nguyen, Tan H. ; Goddard, Lynford L ; Popescu, Gabriel. / Diffraction phase microscopy : Principles and applications in materials and life sciences. In: Advances in Optics and Photonics. 2014 ; Vol. 6, No. 1. pp. 57-119.
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