Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease

Jessie L. Burns, Manabu T. Nakamura, David W.L. Ma

Research output: Contribution to journalReview articlepeer-review

Abstract

Dietary fatty acids are associated with the development of many chronic diseases, such as obesity, diabetes, cardiovascular disease, metabolic syndrome, and several cancers. This review explores the literature surrounding the combined and individual roles of n-6 PUFAs linoleic acid (LA) and arachidonic acid (AA) as they relate to immune and inflammatory response, cardiovascular health, liver health, and cancer. The evidence suggests that a pro-inflammatory view of LA and AA may be over simplified. Overall, this review highlights gaps in our understanding of the biological roles of LA, AA and their complex relationship with n-3 PUFA and the need for future studies that examine the roles of individual fatty acids, rather than groups.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume135
DOIs
StatePublished - Aug 2018
Externally publishedYes

Keywords

  • Arachidonic acid (AA)
  • Cancer
  • Cardiovascular health
  • Inflammation
  • Linoleic acid (LA)
  • Liver health

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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