Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease

Jessie L. Burns; Manabu T. Nakamura; David W.L. Ma

doi:10.1016/j.plefa.2018.05.004

Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease

Jessie L. Burns, Manabu T. Nakamura, David W.L. Ma

Research output: Contribution to journal › Review article › peer-review

Abstract

Dietary fatty acids are associated with the development of many chronic diseases, such as obesity, diabetes, cardiovascular disease, metabolic syndrome, and several cancers. This review explores the literature surrounding the combined and individual roles of n-6 PUFAs linoleic acid (LA) and arachidonic acid (AA) as they relate to immune and inflammatory response, cardiovascular health, liver health, and cancer. The evidence suggests that a pro-inflammatory view of LA and AA may be over simplified. Overall, this review highlights gaps in our understanding of the biological roles of LA, AA and their complex relationship with n-3 PUFA and the need for future studies that examine the roles of individual fatty acids, rather than groups.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	135
DOIs	https://doi.org/10.1016/j.plefa.2018.05.004
State	Published - Aug 2018
Externally published	Yes

Keywords

Arachidonic acid (AA)
Cancer
Cardiovascular health
Inflammation
Linoleic acid (LA)
Liver health

ASJC Scopus subject areas

Clinical Biochemistry
Cell Biology

Online availability

10.1016/j.plefa.2018.05.004

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title = "Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease",

abstract = "Dietary fatty acids are associated with the development of many chronic diseases, such as obesity, diabetes, cardiovascular disease, metabolic syndrome, and several cancers. This review explores the literature surrounding the combined and individual roles of n-6 PUFAs linoleic acid (LA) and arachidonic acid (AA) as they relate to immune and inflammatory response, cardiovascular health, liver health, and cancer. The evidence suggests that a pro-inflammatory view of LA and AA may be over simplified. Overall, this review highlights gaps in our understanding of the biological roles of LA, AA and their complex relationship with n-3 PUFA and the need for future studies that examine the roles of individual fatty acids, rather than groups.",

keywords = "Arachidonic acid (AA), Cancer, Cardiovascular health, Inflammation, Linoleic acid (LA), Liver health",

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AU - Burns, Jessie L.

AU - Nakamura, Manabu T.

AU - Ma, David W.L.

PY - 2018/8

Y1 - 2018/8

N2 - Dietary fatty acids are associated with the development of many chronic diseases, such as obesity, diabetes, cardiovascular disease, metabolic syndrome, and several cancers. This review explores the literature surrounding the combined and individual roles of n-6 PUFAs linoleic acid (LA) and arachidonic acid (AA) as they relate to immune and inflammatory response, cardiovascular health, liver health, and cancer. The evidence suggests that a pro-inflammatory view of LA and AA may be over simplified. Overall, this review highlights gaps in our understanding of the biological roles of LA, AA and their complex relationship with n-3 PUFA and the need for future studies that examine the roles of individual fatty acids, rather than groups.

AB - Dietary fatty acids are associated with the development of many chronic diseases, such as obesity, diabetes, cardiovascular disease, metabolic syndrome, and several cancers. This review explores the literature surrounding the combined and individual roles of n-6 PUFAs linoleic acid (LA) and arachidonic acid (AA) as they relate to immune and inflammatory response, cardiovascular health, liver health, and cancer. The evidence suggests that a pro-inflammatory view of LA and AA may be over simplified. Overall, this review highlights gaps in our understanding of the biological roles of LA, AA and their complex relationship with n-3 PUFA and the need for future studies that examine the roles of individual fatty acids, rather than groups.

KW - Arachidonic acid (AA)

KW - Cancer

KW - Cardiovascular health

KW - Inflammation

KW - Linoleic acid (LA)

KW - Liver health

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Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease

Abstract

Keywords

ASJC Scopus subject areas

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