TY - JOUR
T1 - Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease
AU - Burns, Jessie L.
AU - Nakamura, Manabu T.
AU - Ma, David W.L.
PY - 2018/8
Y1 - 2018/8
N2 - Dietary fatty acids are associated with the development of many chronic diseases, such as obesity, diabetes, cardiovascular disease, metabolic syndrome, and several cancers. This review explores the literature surrounding the combined and individual roles of n-6 PUFAs linoleic acid (LA) and arachidonic acid (AA) as they relate to immune and inflammatory response, cardiovascular health, liver health, and cancer. The evidence suggests that a pro-inflammatory view of LA and AA may be over simplified. Overall, this review highlights gaps in our understanding of the biological roles of LA, AA and their complex relationship with n-3 PUFA and the need for future studies that examine the roles of individual fatty acids, rather than groups.
AB - Dietary fatty acids are associated with the development of many chronic diseases, such as obesity, diabetes, cardiovascular disease, metabolic syndrome, and several cancers. This review explores the literature surrounding the combined and individual roles of n-6 PUFAs linoleic acid (LA) and arachidonic acid (AA) as they relate to immune and inflammatory response, cardiovascular health, liver health, and cancer. The evidence suggests that a pro-inflammatory view of LA and AA may be over simplified. Overall, this review highlights gaps in our understanding of the biological roles of LA, AA and their complex relationship with n-3 PUFA and the need for future studies that examine the roles of individual fatty acids, rather than groups.
KW - Arachidonic acid (AA)
KW - Cancer
KW - Cardiovascular health
KW - Inflammation
KW - Linoleic acid (LA)
KW - Liver health
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U2 - 10.1016/j.plefa.2018.05.004
DO - 10.1016/j.plefa.2018.05.004
M3 - Review article
C2 - 30103919
AN - SCOPUS:85048454375
SN - 0952-3278
VL - 135
SP - 1
EP - 4
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
ER -