Differential scattering of circularly polarized light as a unique probe of polynucleosome superstructures - A simulation by multiple scattering of dipoles

S. Zietz, A. Belmont, C. Nicolini

Research output: Contribution to journalArticlepeer-review

Abstract

A theoretical approach to modeling Circular Intensity Differential Scattering (CIDS) of native chromatin as multiple scattering of dipoles is discussed without the Born approximation. The model can explain the experimental data in the literature. It is shown that CIDS contains more structural information than does total light scattering and to a good approximation is independent of the length of the scattering molecules. Finally, CIDS in conjunction with traditional light scattering measurements should aid in discriminating between various alternative models of higher order chromatin structure now being proposed. Generalization of this theoretical study to other complex biomolecular structures, is also briefly discussed.

Original languageEnglish (US)
Pages (from-to)163-187
Number of pages25
JournalCell Biophysics
Volume5
Issue number3
DOIs
StatePublished - Sep 1 1983
Externally publishedYes

Keywords

  • Circular Intensity Differential Scattering, of chromatin
  • differential scattering, of chromatin
  • dipoles, multiple scattering of
  • polarized light scattering studies, on chromatin
  • polynucleosome superstructures, differential scattering of

ASJC Scopus subject areas

  • Biophysics
  • Cell Biology

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