Differential rearing affects responsiveness of rats to depressant and convulsant drugs

Janice M. Juraska; William T. Greenough; John W. Conlee

doi:10.1016/S0031-9384(83)80008-0

Differential rearing affects responsiveness of rats to depressant and convulsant drugs

Janice M. Juraska, William T. Greenough, John W. Conlee

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of postweaning housing in environmental complexity (EC) or isolation cage (IC) conditions upon the development of anesthesia following sodium pentobarbital administration and upon seizure susceptibility following metrazol administration were studied in separate groups of rats. Male and female EC rats lost the righting reflex and developed unconsciousness more rapidly following sodium pentobarbital injection (105 mg/kg, IP) than did littermate IC rats. Male EC and IC rats did not differ in the CD₅₀ (50% convulsion dosage by log probit analysis) following injection of a range of metrazol doses (20 to 35 mg/kg, IP) when they were kept in a quiet dimly lighted room. However, the addition of stroboscopic light stimulation (1-100 Hz) to the above procedure (doses 17.5 to 30 mg/kg) reduced the CD₅₀ for the IC rats but did not affect the CD₅₀ for the EC rats. The results support the view that brain excitability is lower in animals reared in environments providing higher levels of sensory stimulation.

Original language	English (US)
Pages (from-to)	711-715
Number of pages	5
Journal	Physiology and Behavior
Volume	31
Issue number	5
DOIs	https://doi.org/10.1016/S0031-9384(83)80008-0
State	Published - 1983

Keywords

Complex environment
Development
Isolation
Metrazol
Sodium pentobarbital Brain excitability

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

Online availability

10.1016/S0031-9384(83)80008-0

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title = "Differential rearing affects responsiveness of rats to depressant and convulsant drugs",

abstract = "The effects of postweaning housing in environmental complexity (EC) or isolation cage (IC) conditions upon the development of anesthesia following sodium pentobarbital administration and upon seizure susceptibility following metrazol administration were studied in separate groups of rats. Male and female EC rats lost the righting reflex and developed unconsciousness more rapidly following sodium pentobarbital injection (105 mg/kg, IP) than did littermate IC rats. Male EC and IC rats did not differ in the CD50 (50% convulsion dosage by log probit analysis) following injection of a range of metrazol doses (20 to 35 mg/kg, IP) when they were kept in a quiet dimly lighted room. However, the addition of stroboscopic light stimulation (1-100 Hz) to the above procedure (doses 17.5 to 30 mg/kg) reduced the CD50 for the IC rats but did not affect the CD50 for the EC rats. The results support the view that brain excitability is lower in animals reared in environments providing higher levels of sensory stimulation.",

keywords = "Complex environment, Development, Isolation, Metrazol, Sodium pentobarbital Brain excitability",

author = "Juraska, {Janice M.} and Greenough, {William T.} and Conlee, {John W.}",

note = "Funding Information: ~Supported by NIH HDI4949 and a MacArlhur Foundation grant (to J.M.3.) and NSF BNS 8216916 (to W.T.G.).",

year = "1983",

doi = "10.1016/S0031-9384(83)80008-0",

language = "English (US)",

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journal = "Physiology and Behavior",

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AU - Juraska, Janice M.

AU - Greenough, William T.

AU - Conlee, John W.

N1 - Funding Information: ~Supported by NIH HDI4949 and a MacArlhur Foundation grant (to J.M.3.) and NSF BNS 8216916 (to W.T.G.).

PY - 1983

Y1 - 1983

N2 - The effects of postweaning housing in environmental complexity (EC) or isolation cage (IC) conditions upon the development of anesthesia following sodium pentobarbital administration and upon seizure susceptibility following metrazol administration were studied in separate groups of rats. Male and female EC rats lost the righting reflex and developed unconsciousness more rapidly following sodium pentobarbital injection (105 mg/kg, IP) than did littermate IC rats. Male EC and IC rats did not differ in the CD50 (50% convulsion dosage by log probit analysis) following injection of a range of metrazol doses (20 to 35 mg/kg, IP) when they were kept in a quiet dimly lighted room. However, the addition of stroboscopic light stimulation (1-100 Hz) to the above procedure (doses 17.5 to 30 mg/kg) reduced the CD50 for the IC rats but did not affect the CD50 for the EC rats. The results support the view that brain excitability is lower in animals reared in environments providing higher levels of sensory stimulation.

AB - The effects of postweaning housing in environmental complexity (EC) or isolation cage (IC) conditions upon the development of anesthesia following sodium pentobarbital administration and upon seizure susceptibility following metrazol administration were studied in separate groups of rats. Male and female EC rats lost the righting reflex and developed unconsciousness more rapidly following sodium pentobarbital injection (105 mg/kg, IP) than did littermate IC rats. Male EC and IC rats did not differ in the CD50 (50% convulsion dosage by log probit analysis) following injection of a range of metrazol doses (20 to 35 mg/kg, IP) when they were kept in a quiet dimly lighted room. However, the addition of stroboscopic light stimulation (1-100 Hz) to the above procedure (doses 17.5 to 30 mg/kg) reduced the CD50 for the IC rats but did not affect the CD50 for the EC rats. The results support the view that brain excitability is lower in animals reared in environments providing higher levels of sensory stimulation.

KW - Complex environment

KW - Development

KW - Isolation

KW - Metrazol

KW - Sodium pentobarbital Brain excitability

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Differential rearing affects responsiveness of rats to depressant and convulsant drugs

Abstract

Keywords

ASJC Scopus subject areas

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