Differential membrane binding mechanics of synaptotagmin isoforms observed in atomic detail

Keyphrases

• Membrane Binding 100%
• Synaptotagmin 100%
• C2 Domain 80%
• Synaptotagmin-7 80%
• Vesicle Fusion 40%
• Ca2+ 20%
• Molecular Dynamics Simulation 20%
• Membrane Protein 20%
• Head Group 20%
• Methionine 20%
• Human Body 20%
• Binding Kinetics 20%
• Positive Charge 20%
• Membrane Mimetics 20%
• SNARE Complex 20%
• Bilayer Model 20%
• Close Contact 20%
• Protein Sequence 20%
• Small Protein 20%
• Ca2+ Binding 20%
• Anionic Phospholipids 20%
• Sequence Modification 20%
• Energetic Cost 20%
• Anionic Membrane 20%
• Replica-exchange Umbrella Sampling 20%

Biochemistry, Genetics and Molecular Biology

• Isoform 100%
• Synaptotagmin 100%
• Membrane Binding 100%
• C2 Domain 66%
• Synaptotagmin 1 50%
• Vesicle Fusion 33%
• Dynamics 16%
• Methionine 16%
• Membrane Protein 16%
• Energy Transfer 16%
• Peptide Sequence 16%
• Binding Kinetics 16%
• Phospholipid 16%
• Umbrella Sampling 16%