Consequences of alternative H-bonding: Raman spectra of oxygenated intermediates of Nanodisc-incorporated human CYP17 in the presence of natural substrates (pregnenolone and progesterone) directly confirm that substrate structure effectively alters hydrogen-bonding interactions with the critical Fe-O-O fragment and dictates its predisposition for one of two alternative reaction pathways. Such substrate control has profound physiological implications.
|Original language||English (US)|
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|State||Published - May 10 2013|
- Raman spectroscopy
- heme proteins
ASJC Scopus subject areas