Dietary Peptides from Phaseolus vulgaris L. Reduced AOM/DSS-Induced Colitis-Associated Colon Carcinogenesis in Balb/c Mice

Diego A. Luna-Vital, Elvira González de Mejía, Guadalupe Loarca-Piña

Research output: Contribution to journalArticlepeer-review

Abstract

The aim was to evaluate the antineoplastic potential of a previously characterized peptide extract from the non-digestible fraction of common bean cv. Azufrado Higuera (AH) and its most abundant pure peptide GLTSK, in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colitis-associated colon carcinogenesis Balb/c mice model. The healthy control (C-) had no induction and no treatment, and the induced control (C+) had induction but no treatment. Groups AH and GLTSK were administered 50 mg/kg-bw of AH or GLTSK, respectively. The administration of AH and GLTSK decreased (p < 0.05) the disease activity index (DAI) compared to C+ (5.8, 9.1, 11.8, respectively). Furthermore, AH reduced the number of evident neoplasms compared to group C+ (1.8, 5.9 neoplasms/mice, respectively). The results suggest that peptides from common bean cv. Azufrado Higuera could prevent colitis-associated colon carcinogenesis.

Original languageEnglish (US)
Pages (from-to)445-447
Number of pages3
JournalPlant Foods for Human Nutrition
Volume72
Issue number4
DOIs
StatePublished - Dec 1 2017

Keywords

  • Anticancer peptides
  • Bioactive peptides
  • Colon carcinogenesis
  • Common bean

ASJC Scopus subject areas

  • Food Science
  • Chemistry (miscellaneous)

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