Clinically used anesthetics show amnestic, sedative, hypnotic and immobilizing properties. On a molecular level these drugs affect several receptors in the cell membrane of neurons. By using genetically engineered mice a linkage can now be made between actions on certain receptors and clinically desired and undesired effects. Experiments show that a certain GABA A receptor subtype mediates hypnosis and immobility, whereas another subtype is involved in side-effects like sedation and hypothermia. These findings form the basis for the development of new drugs, acting highly specific and with fewer side-effects.
|Translated title of the contribution||The GABA A receptor family. Possibilities for the development of better anesthetics|
|Number of pages||9|
|State||Published - Mar 2006|
- GABA receptor subtypes
- Intravenous anesthetics
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine