DIC and granulomatous vasculitis in a dog with disseminated histoplasmosis

Chen Gilor, Marcella D. Ridgway, Kuldeep Singh

Research output: Contribution to journalArticlepeer-review


Disseminated histoplasmosis and disseminated intravascular coagulopathy were diagnosed in a 7 mo old, female spayed mixed-breed dog. The dog improved transiently with supportive care, but deteriorated shortly after initiation of antifungal therapy. The dog was subsequently euthanized. At necropsy, marked granulomatous vasculitis was identified in all affected organs. The tunicae and laminae of the arteries and arterioles were obscured by epithelioid macrophages and multinucleated giant cells admixed with necrotic material. Intracytoplasmic yeast were present within some of these macrophages. To the authors' knowledge, this is the first reported case of granulomatous vasculitis associated with Histoplasma capsulatum in a dog.

Original languageEnglish (US)
Pages (from-to)e26-e30
JournalJournal of the American Animal Hospital Association
Issue number3
StatePublished - May 2011

ASJC Scopus subject areas

  • Small Animals


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