(matrix presented) The trichlorosilyl enolates derived from chiral ethyl ketones bearing a β-hydroxyl group and an α-stereogenic center were employed in the phosphoramide-catalyzed aldol reaction. The addition of Z-enolates to achiral aldehydes produced aldol products in good yields and high syn relative diastereoselectivities. The internal diastereoselectivity is controlled by the catalyst configuration, allowing for selective formation of either syn diastereomer.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry