Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands

Filippo Minutolo, Michela Antonello, Simone Bertini, Giorgio Placanica, Simona Rapposelli, Kathryn E. Carlson, John A. Katzenellenbogen, Marco Macchia

Research output: Contribution to journalArticlepeer-review


3,4-Diphenylsalicylaldoxime and 3,4-diphenylanthranylaldoxime derivatives, containing small groups (methyl or ethyl) on the imine carbon atom, were synthesized and submitted to biological assays. Binding tests performed on uterine cytosol estrogen receptor (ER) preparation and on purified full-length human ERα and ERβ, showed that the newly synthesised compounds exhibit considerably lower binding affinities with respect to reference non-substituted 3,4-salicylaldoxime.

Original languageEnglish (US)
Pages (from-to)601-607
Number of pages7
Issue number8
StatePublished - Aug 2004

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery


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