TY - JOUR
T1 - Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands
AU - Minutolo, Filippo
AU - Antonello, Michela
AU - Bertini, Simone
AU - Placanica, Giorgio
AU - Rapposelli, Simona
AU - Carlson, Kathryn E.
AU - Katzenellenbogen, John A.
AU - Macchia, Marco
PY - 2004/8
Y1 - 2004/8
N2 - 3,4-Diphenylsalicylaldoxime and 3,4-diphenylanthranylaldoxime derivatives, containing small groups (methyl or ethyl) on the imine carbon atom, were synthesized and submitted to biological assays. Binding tests performed on uterine cytosol estrogen receptor (ER) preparation and on purified full-length human ERα and ERβ, showed that the newly synthesised compounds exhibit considerably lower binding affinities with respect to reference non-substituted 3,4-salicylaldoxime.
AB - 3,4-Diphenylsalicylaldoxime and 3,4-diphenylanthranylaldoxime derivatives, containing small groups (methyl or ethyl) on the imine carbon atom, were synthesized and submitted to biological assays. Binding tests performed on uterine cytosol estrogen receptor (ER) preparation and on purified full-length human ERα and ERβ, showed that the newly synthesised compounds exhibit considerably lower binding affinities with respect to reference non-substituted 3,4-salicylaldoxime.
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U2 - 10.1016/j.farmac.2004.01.007
DO - 10.1016/j.farmac.2004.01.007
M3 - Article
C2 - 15262529
AN - SCOPUS:3242704056
SN - 1860-7179
VL - 59
SP - 601
EP - 607
JO - Farmaco
JF - Farmaco
IS - 8
ER -