Diagnostic Approach to Small Animal Bleeding Disorders

Jennifer Herring, Maureen McMichael

Research output: Contribution to journalReview article

Abstract

A well-designed and executed diagnostic approach to patients with bleeding disorders is critical to determine disease etiology and guide therapeutic measures. This systematic process begins with a comprehensive history and physical examination, followed by laboratory tests of primary hemostasis (platelet enumeration, platelet function testing, and von Willebrand factor assays), secondary hemostasis (prothrombin time, activated partial thromboplastin time, activated clotting time, and individual factor deficiencies), and fibrinolysis (fibrinogen activity, thrombin time, fibrin degradation products, D-dimers), dependent on the clinical picture. Equally valuable are proper specimen collection, handling, and storage methods, which provide reliable and reproducible result interpretation. This review will emphasize the common diagnostic tools and blood sampling techniques important to the workup of hemostatic diseases as well as provide an overview of advanced clinical and research methods and equipment available to assist our bleeding veterinary patients, including thromboelastography/thromboelastometry, calibrated automated thrombogram, and the thrombin-antithrombin assay.

Original languageEnglish (US)
Pages (from-to)73-80
Number of pages8
JournalTopics in Companion Animal Medicine
Volume27
Issue number2
DOIs
StatePublished - May 1 2012

Fingerprint

Thrombelastography
Specimen Handling
hemostasis
thrombin
Hemostasis
hemorrhage
Blood Platelets
Afibrinogenemia
research equipment
Hemorrhage
fibrinolysis
Thrombin Time
Fibrin Fibrinogen Degradation Products
thromboplastin
blood coagulation factors
prothrombin
Antithrombins
Partial Thromboplastin Time
fibrin
Prothrombin Time

Keywords

  • Cat
  • Coagulation
  • Dog
  • Fibrinolysis
  • Hemorrhage
  • Primary hemostasis
  • Secondary hemostasis

ASJC Scopus subject areas

  • Small Animals

Cite this

Diagnostic Approach to Small Animal Bleeding Disorders. / Herring, Jennifer; McMichael, Maureen.

In: Topics in Companion Animal Medicine, Vol. 27, No. 2, 01.05.2012, p. 73-80.

Research output: Contribution to journalReview article

@article{676d6aea13414843a6f645cc6606bf37,
title = "Diagnostic Approach to Small Animal Bleeding Disorders",
abstract = "A well-designed and executed diagnostic approach to patients with bleeding disorders is critical to determine disease etiology and guide therapeutic measures. This systematic process begins with a comprehensive history and physical examination, followed by laboratory tests of primary hemostasis (platelet enumeration, platelet function testing, and von Willebrand factor assays), secondary hemostasis (prothrombin time, activated partial thromboplastin time, activated clotting time, and individual factor deficiencies), and fibrinolysis (fibrinogen activity, thrombin time, fibrin degradation products, D-dimers), dependent on the clinical picture. Equally valuable are proper specimen collection, handling, and storage methods, which provide reliable and reproducible result interpretation. This review will emphasize the common diagnostic tools and blood sampling techniques important to the workup of hemostatic diseases as well as provide an overview of advanced clinical and research methods and equipment available to assist our bleeding veterinary patients, including thromboelastography/thromboelastometry, calibrated automated thrombogram, and the thrombin-antithrombin assay.",
keywords = "Cat, Coagulation, Dog, Fibrinolysis, Hemorrhage, Primary hemostasis, Secondary hemostasis",
author = "Jennifer Herring and Maureen McMichael",
year = "2012",
month = "5",
day = "1",
doi = "10.1053/j.tcam.2012.07.004",
language = "English (US)",
volume = "27",
pages = "73--80",
journal = "Topics in Companion Animal Medicine",
issn = "1938-9736",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Diagnostic Approach to Small Animal Bleeding Disorders

AU - Herring, Jennifer

AU - McMichael, Maureen

PY - 2012/5/1

Y1 - 2012/5/1

N2 - A well-designed and executed diagnostic approach to patients with bleeding disorders is critical to determine disease etiology and guide therapeutic measures. This systematic process begins with a comprehensive history and physical examination, followed by laboratory tests of primary hemostasis (platelet enumeration, platelet function testing, and von Willebrand factor assays), secondary hemostasis (prothrombin time, activated partial thromboplastin time, activated clotting time, and individual factor deficiencies), and fibrinolysis (fibrinogen activity, thrombin time, fibrin degradation products, D-dimers), dependent on the clinical picture. Equally valuable are proper specimen collection, handling, and storage methods, which provide reliable and reproducible result interpretation. This review will emphasize the common diagnostic tools and blood sampling techniques important to the workup of hemostatic diseases as well as provide an overview of advanced clinical and research methods and equipment available to assist our bleeding veterinary patients, including thromboelastography/thromboelastometry, calibrated automated thrombogram, and the thrombin-antithrombin assay.

AB - A well-designed and executed diagnostic approach to patients with bleeding disorders is critical to determine disease etiology and guide therapeutic measures. This systematic process begins with a comprehensive history and physical examination, followed by laboratory tests of primary hemostasis (platelet enumeration, platelet function testing, and von Willebrand factor assays), secondary hemostasis (prothrombin time, activated partial thromboplastin time, activated clotting time, and individual factor deficiencies), and fibrinolysis (fibrinogen activity, thrombin time, fibrin degradation products, D-dimers), dependent on the clinical picture. Equally valuable are proper specimen collection, handling, and storage methods, which provide reliable and reproducible result interpretation. This review will emphasize the common diagnostic tools and blood sampling techniques important to the workup of hemostatic diseases as well as provide an overview of advanced clinical and research methods and equipment available to assist our bleeding veterinary patients, including thromboelastography/thromboelastometry, calibrated automated thrombogram, and the thrombin-antithrombin assay.

KW - Cat

KW - Coagulation

KW - Dog

KW - Fibrinolysis

KW - Hemorrhage

KW - Primary hemostasis

KW - Secondary hemostasis

UR - http://www.scopus.com/inward/record.url?scp=84866980426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866980426&partnerID=8YFLogxK

U2 - 10.1053/j.tcam.2012.07.004

DO - 10.1053/j.tcam.2012.07.004

M3 - Review article

C2 - 23031459

AN - SCOPUS:84866980426

VL - 27

SP - 73

EP - 80

JO - Topics in Companion Animal Medicine

JF - Topics in Companion Animal Medicine

SN - 1938-9736

IS - 2

ER -