Diagnosis of Alzheimer’s Disease Using Convolutional Neural Network With Select Slices by Landmark on Hippocampus in MRI Images

Alzheimer's disease (AD) is a major public health priority. Hippocampus is one of the most affected areas of the brain and is easily accessible as a biomarker using MRI images in machine learning for diagnosing AD. In machine learning, using entire MRI image slices showed lower accuracy for AD classification. We present the select slices method by landmarks on the hippocampus region in MRI images. This study aims to see which views of MRI images have higher accuracy for AD classification. Then, to get the value of three views and categories, we used multiclass classification with the publicly available Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset using Resnet50 and LeNet. The models were used in a total dataset of 4,500 MRI slices in three views and categories. Our study demonstrated that the selecting slices performed better than using entire slices in MRI images for AD classification. Our method improves the accuracy of machine learning, and the coronal view showed higher accuracy. This method played a significant role in improving the accuracy of machine learning performance. The results for the coronal view were similar to the medical experts usually used to diagnose AD. We also found that LeNet models became the potential model for AD classification.