Dexamethasone and estrogen regulate Xenopus laevis albumin mRNA levels

Cynthia L. Jackson, David J. Shapiro

Research output: Contribution to journalArticlepeer-review

Abstract

The regulation of albumin mRNA levels by steroid hormones was examined in a primary Xenopus liver culture system. In the absence of exogenous steroid hormone, albumin mRNA levels declined rapidly in culture. Dexamethasone is required for preservation of albumin mRNA levels in culture and effects a > 10 fold induction of albumin mRNA in cultures maintained in steroid hormone-free medium. Estrogen can override the effect of dexamethasone and elicits a decline of greater than 80% in albumin mRNA levels. Our cDNA clones of the mRNAs encoding the two 74,000 dalton and one 72,000 dalton cellular albumins allowed us to show that all three albumin mRNAs were down regulated by estrogen.

Original languageEnglish (US)
Pages (from-to)8-15
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume136
Issue number1
DOIs
StatePublished - Apr 14 1986

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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