Developmental Origins of Hypothalamic Cells Controlling Reproduction

Matthew Joseph Biehl, Lori T Raetzman

Research output: Contribution to journalReview article

Abstract

The hypothalamus-pituitary-gonadal (HPG) axis is the most critical modulator of reproductive function. Genetic or environmental insults to the HPG axis during developmental windows can persist into adulthood, and processes such as gonadal hormone synthesis, timing of puberty, and fertility can be affected. At the level of the hypothalamus, multiple regions develop at different times and are under the control of a concert of signaling pathways and transcription factors required for their patterning and maturation. In this review, we highlight factors and pathways involved in specification and ultimate differentiation of neuronal and other cellular subtypes of the hypothalamus contributing to the HPG axis. Specifically, we discuss development of the arcuate and anteroventral periventricular nuclei, as well as forebrain development as it relates to reproductive function. Precise control of kisspeptin and gonadotropin-releasing hormone neuron, as well as tanycyte, development is necessary for understanding and ultimately treating developmental disruptions resulting in infertility.

Original languageEnglish (US)
Pages (from-to)121-129
Number of pages9
JournalSeminars in Reproductive Medicine
Volume35
Issue number2
DOIs
StatePublished - Mar 1 2017

Fingerprint

Hypothalamus
Reproduction
Kisspeptins
Gonadal Hormones
Anterior Hypothalamus
Puberty
Prosencephalon
Gonadotropin-Releasing Hormone
Infertility
Fertility
Transcription Factors
Neurons

Keywords

  • GnRH
  • development
  • hypothalamus
  • kisspeptin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Physiology (medical)

Cite this

Developmental Origins of Hypothalamic Cells Controlling Reproduction. / Biehl, Matthew Joseph; Raetzman, Lori T.

In: Seminars in Reproductive Medicine, Vol. 35, No. 2, 01.03.2017, p. 121-129.

Research output: Contribution to journalReview article

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