Development of semi-continuous and continuous flow bioreactors for the high level production of chloroperoxidase

Steven R. Blanke, San Yi, Lowell P. Hager

Research output: Contribution to journalArticlepeer-review

Abstract

Continuous and semi-continuous flow bioreactors have been developed for the production of chloroperoxidase, which is secreted by the fungus Caldariomyces fumago. The semi-continuous system facilitated the harvest of mycelium-free supernatant for 200 days from a single inoculum, with enzyme levels greater than 600 mg/l during the first 80 days. The continuous flow bioreactor yielded essentially pure enzyme at the rate of 117 mg/day.

Original languageEnglish (US)
Pages (from-to)769-774
Number of pages6
JournalBiotechnology Letters
Volume11
Issue number11
DOIs
StatePublished - Nov 1 1989

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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