Development of peptide nucleic acid assemblies for application in drug delivery and molecular sensing

Felice N. Butler, Oguz Elibol, Bridget D. Hines, Bobby Reddy, Rashid Bashir, Donald E. Bergstrom

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We are exploring peptide nucleic acid (PNA) assemblies as interesting scaffolds for the fabrication of nanomaterials relevant to the diagnosis and treatment of disease. The first assembly is a PNA/LNA (locked nucleic acid) duplex employed in the heat-mediated selective functionalization of arrayed nanodevices. The ultimate goal of this arrayed approach is the detection of multiple miRNA sequences simultaneously with high throughput and specificity. Since miRNAs have been linked to certain disease states in various types of cancers, their detection may help lead to early diagnosis in a clinical setting. A second type of assembly has been created from PNA sequences that self-assemble based hybridization in the parallel direction. The resulting PNA nanoparticles traverse breast cancer cell membranes, making them a promising platform for the delivery of oligonucleotide probes.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Pages369-371
Number of pages3
StatePublished - Oct 1 2008
Event2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008 - Quebec City, QC, United States
Duration: Jun 1 2008Jun 5 2008

Publication series

NameTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Volume2

Other

Other2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008
CountryUnited States
CityQuebec City, QC
Period6/1/086/5/08

Keywords

  • Array
  • Lna
  • MCF-7
  • Nanoparticles
  • Pna

ASJC Scopus subject areas

  • Mechanical Engineering

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  • Cite this

    Butler, F. N., Elibol, O., Hines, B. D., Reddy, B., Bashir, R., & Bergstrom, D. E. (2008). Development of peptide nucleic acid assemblies for application in drug delivery and molecular sensing. In Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008 (pp. 369-371). (Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008; Vol. 2).