Development of oxacillin resistance in a patient with recurrent Staphylococcus aureus bacteremia

Eileen M. Burd; Mohammad Tauqeer Alam; Karla D. Passalacqua; Ameeta S. Kalokhe; Molly E. Eaton; Sarah W. Satola; Colleen S. Kraft; Timothy D. Read

doi:10.1128/JCM.00615-14

Development of oxacillin resistance in a patient with recurrent Staphylococcus aureus bacteremia

Eileen M. Burd, Mohammad Tauqeer Alam, Karla D. Passalacqua, Ameeta S. Kalokhe, Molly E. Eaton, Sarah W. Satola, Colleen S. Kraft, Timothy D. Read

Research output: Contribution to journal › Article › peer-review

Abstract

Whole-genome sequencing was used to compare longitudinal isolates of Staphylococcus aureus that developed resistance to oxacillin (MIC up to 16 μg/ml). The mecA gene was absent. A novel 5-bp TATCC frameshift insertion in a gene encoding an ABC transporter similar to that of the teichoic acid translocation ATP-binding protein TagH and a 3-bp GCT nonframeshift insertion in the pdhA pyruvate dehydrogenase gene were detected in the oxacillin-resistant isolates.

Original language	English (US)
Pages (from-to)	3114-3117
Number of pages	4
Journal	Journal of Clinical Microbiology
Volume	52
Issue number	8
DOIs	https://doi.org/10.1128/JCM.00615-14
State	Published - Aug 2014
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)

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10.1128/JCM.00615-14

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title = "Development of oxacillin resistance in a patient with recurrent Staphylococcus aureus bacteremia",

abstract = "Whole-genome sequencing was used to compare longitudinal isolates of Staphylococcus aureus that developed resistance to oxacillin (MIC up to 16 μg/ml). The mecA gene was absent. A novel 5-bp TATCC frameshift insertion in a gene encoding an ABC transporter similar to that of the teichoic acid translocation ATP-binding protein TagH and a 3-bp GCT nonframeshift insertion in the pdhA pyruvate dehydrogenase gene were detected in the oxacillin-resistant isolates.",

author = "Burd, {Eileen M.} and Alam, {Mohammad Tauqeer} and Passalacqua, {Karla D.} and Kalokhe, {Ameeta S.} and Eaton, {Molly E.} and Satola, {Sarah W.} and Kraft, {Colleen S.} and Read, {Timothy D.}",

year = "2014",

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AU - Burd, Eileen M.

AU - Alam, Mohammad Tauqeer

AU - Passalacqua, Karla D.

AU - Kalokhe, Ameeta S.

AU - Eaton, Molly E.

AU - Satola, Sarah W.

AU - Kraft, Colleen S.

AU - Read, Timothy D.

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AB - Whole-genome sequencing was used to compare longitudinal isolates of Staphylococcus aureus that developed resistance to oxacillin (MIC up to 16 μg/ml). The mecA gene was absent. A novel 5-bp TATCC frameshift insertion in a gene encoding an ABC transporter similar to that of the teichoic acid translocation ATP-binding protein TagH and a 3-bp GCT nonframeshift insertion in the pdhA pyruvate dehydrogenase gene were detected in the oxacillin-resistant isolates.

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Development of oxacillin resistance in a patient with recurrent Staphylococcus aureus bacteremia

Abstract

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