Development of Nitroreductase-Activatable Fluoroquinolone Prodrugs Exhibiting Attenuated Magnesium Ion Binding

Keyphrases

• Prodrug 100%
• Anion Binding 100%
• Magnesium Ion 100%
• Fluoroquinolones 100%
• Nitroreductase 100%
• α-keto Acids 66%
• Ciprofloxacin 66%
• Levofloxacin 66%
• Healthy Tissue 33%
• Functional Groups 33%
• Cartilage 33%
• Linker 33%
• Biologically Relevant 33%
• Clinical Application 33%
• Thiols 33%
• Esters 33%
• Mitochondria 33%
• Antibiotics 33%
• Esterification 33%
• Systemic Administration 33%
• Quinolones 33%
• Enzymatic System 33%
• Competition Assay 33%
• Human Patients 33%
• Anticancer Agents 33%
• Cross-reactivity 33%
• Off-target Effects 33%
• Bacterial Infection 33%
• Esterase Activity 33%
• Achilles Tendon 33%
• Spontaneous Hydrolysis 33%
• Ketoesters 33%
• Warhead 33%
• Self-immolative 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Prodrug 100%
• Magnesium Ion 100%
• Quinolone Derivative 100%
• Nitroreductase 100%
• Oxoacid 50%
• Ciprofloxacin 50%
• Levofloxacin 50%
• Thiol 25%
• Functional Groups 25%
• Antibiotic Agent 25%
• Systemic Administration 25%
• Anticarcinogen 25%
• Esterase 25%
• Bacterial Infection 25%

Chemistry

• Magnesium Ion 100%
• Prodrug 100%
• Ciprofloxacin 66%
• Levofloxacin 66%
• Thiol 33%
• Quinolone 33%
• Antineoplastic Agent 33%
• Reactive Oxygen Species 33%
• Esterification 33%
• Ketoester 33%