Development of dual-function microbeads embedded with quantum dots and iron oxide nanocrystals for biomedical applications

Tushar Sathe, Shuming Nie

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Nanomaterials, such as semiconductor Quantum Dots (QD) and Iron Oxide nanocrystals possess unique properties that are not available in their bulk phase. Some of these properties include the narrow emission spectra, superior brightness and higher photostability of QDs, and the superparamagnetic properties of Iron Oxide nanocrystals. In the past decade, these two nanomaterials have separately seen widespread use in a variety of biomedical applications ranging from multiplexed biomolecular detection to isolation and magnetic manipulation of disease cells and molecules respectively. Here, we describe a method for combining QDs and Iron Oxide nanocrystals into a micron-sized host material in a rapid fashion. The resulting beads are dual functional, i.e. they are optically encoded, and can be manipulated with a permanent magnet. The beads have great potential in biomedical applications because of the combined ability to enrich and detect multiple target molecules from heterogeneous and diluted biological samples. The development of multifunctional composite materials by combining novel nanomaterials is bound to open avenues for ultrasensitive and quantitative bioassays.

Original languageEnglish (US)
Title of host publicationColloidal Quantum Dots for Biomedical Applications II
StatePublished - 2007
Externally publishedYes
EventColloidal Quantum Dots for Biomedical Applications II - San Jose, CA, United States
Duration: Jan 20 2007Jan 23 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherColloidal Quantum Dots for Biomedical Applications II
Country/TerritoryUnited States
CitySan Jose, CA


  • Bead
  • Fluorescence
  • Iron oxide
  • Magnetic
  • Microsphere
  • Multiplexed assay
  • Quantum dot

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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