Development of a potent invigorator of immune responses endowed with both preventive and therapeutic properties

Gursaran P. Talwar, Jagdish C. Gupta, Abu S. Mustafa, Hemanta K. Kar, Kiran Katoch, Shreemanta K. Parida, Prabhakara P. Reddi, Niyaz Ahmed, Vikram Saini, Somesh Gupta

Research output: Contribution to journalReview article

Abstract

This article reviews briefly the making of an immunoprophylactic-cum-immunotherapeutic vaccine against leprosy. The vaccine is based on cultivable, heat-killed atypical mycobacteria, whose gene sequence is now known. It has been named Mycobacterium indicus pranii. It has received the approval of the Drug Controller General of India and the US Food and Drug Administration. Besides leprosy, M. indicus pranii has found utility in the treatment of category II (“difficult to treat”) tuberculosis. It also heals ugly anogenital warts. It has preventive and therapeutic action against SP2/O myelomas. It is proving to be a potent adjuvant for enhancing antibody titers of a recombinant vaccine against human chorionic gonadotropin, with the potential of preventing pregnancy without derangement of ovulation and menstrual regularity in sexually active women.

Original languageEnglish (US)
Pages (from-to)55-63
Number of pages9
JournalBiologics: Targets and Therapy
Volume11
DOIs
StatePublished - May 2 2017

Keywords

  • Adjuvant
  • Anogenital warts
  • Leprosy
  • Myeloma
  • Tuberculosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Oncology
  • Gastroenterology
  • Pharmacology (medical)

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  • Cite this

    Talwar, G. P., Gupta, J. C., Mustafa, A. S., Kar, H. K., Katoch, K., Parida, S. K., Reddi, P. P., Ahmed, N., Saini, V., & Gupta, S. (2017). Development of a potent invigorator of immune responses endowed with both preventive and therapeutic properties. Biologics: Targets and Therapy, 11, 55-63. https://doi.org/10.2147/BTT.S128308