Development and optimization of near-IR contrast agents for immune cell tracking

Pratixa P. Joshi, Soon Joon Yoon, Yun Sheng Chen, Stanislav Emelianov, Konstantin V. Sokolov

Research output: Contribution to journalArticlepeer-review


Gold nanorods (NRs) are attractive for in vivo imaging due to their high optical cross-sections and tunable absorbance. However, the feasibility of using NRs for cell tracking has not been fully explored. Here, we synthesized dye doped silica-coated NRs as multimodal contrast agents for imaging of macrophages - immune cells which play an important role in cancer and cardiovascular diseases. We showed the importance of silica coating in imaging of NR-labeled cells. Photoacoustic (PA) imaging of NRs labeled macrophages showed high sensitivity. Therefore, these results provide foundation for applications of silica-coated NRs and PA imaging in tracking of immune cells.

Original languageEnglish (US)
Pages (from-to)2609-2618
Number of pages10
JournalBiomedical Optics Express
Issue number11
StatePublished - Nov 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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