Abstract
Null mutations of genes from the NGF family of NTs and their receptors (NTRs) lead to loss/reduction of specific neurons in sensory ganglia; conversely, cutaneous overexpression of NTs results in skin hyperinnervation and increase or no changes in the number of sensory neurons innervating the skin. These neuronal changes are paralleled with loss of specific types of sensory nerve formations in the skin. Therefore, mice carrying mutations in NT or NTR genes represent an ideal model to identify the neuronal dependence of each type of cutaneous sensory nerve ending from a concrete subtype of sensory neuron, since the development, maintenance, and structural integrity of sensory nerve formations depend upon sensory neurons. Results obtained from these mouse strains suggest that TrkA positive neurons are connected to intraepithelial nerve fibers and other sensory nerve formations depending from C and Ad nerve fibers; the neurons expressing TrkB and responding to BDNF and NT-4 innervate Meissner corpuscles, a subpopulation of Merkell cells, some mechanoreceptors of the piloneural complex, and the Ruffini's corpuscles; finally, a subpopulation of neurons, which are responsive to NT-3, support postnatal survival of some intraepithelial nerve fibers and Merkel cells in addition to the muscle mechanoreceptors. On the other hand, changes in NTs and NTRs affect the structure of non-nervous structures of the skin and are at the basis of several cutaneous pathologies. This review is an update about the role of NTs and NTRs in the maintenance of normal cutaneous innervation and maintenance of skin integrity. Microsc. Res. Tech. 73:513-529, 2010.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 513-529 |
| Number of pages | 17 |
| Journal | Microscopy research and technique |
| Volume | 73 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2010 |
| Externally published | Yes |
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Keywords
- Knock-out mice
- Neurotrophins.
- Sensory corpuscles
- Transgenic overexpressing mice
- Trk neurotrophin receptors.
ASJC Scopus subject areas
- Anatomy
- Instrumentation
- Histology
- Medical Laboratory Technology
Cite this
Development and neuronal dependence of cutaneous sensory nerve formations : Lessons from neurotrophins. / MontañO, Juan A.; Pérez-Piñera, Pablo; GarcíA-Suá Rez, Olivia; Cobo, Juan; Vega, Jose A.
In: Microscopy research and technique, Vol. 73, No. 5, 05.2010, p. 513-529.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Development and neuronal dependence of cutaneous sensory nerve formations
T2 - Lessons from neurotrophins
AU - MontañO, Juan A.
AU - Pérez-Piñera, Pablo
AU - GarcíA-Suá Rez, Olivia
AU - Cobo, Juan
AU - Vega, Jose A.
PY - 2010/5
Y1 - 2010/5
N2 - Null mutations of genes from the NGF family of NTs and their receptors (NTRs) lead to loss/reduction of specific neurons in sensory ganglia; conversely, cutaneous overexpression of NTs results in skin hyperinnervation and increase or no changes in the number of sensory neurons innervating the skin. These neuronal changes are paralleled with loss of specific types of sensory nerve formations in the skin. Therefore, mice carrying mutations in NT or NTR genes represent an ideal model to identify the neuronal dependence of each type of cutaneous sensory nerve ending from a concrete subtype of sensory neuron, since the development, maintenance, and structural integrity of sensory nerve formations depend upon sensory neurons. Results obtained from these mouse strains suggest that TrkA positive neurons are connected to intraepithelial nerve fibers and other sensory nerve formations depending from C and Ad nerve fibers; the neurons expressing TrkB and responding to BDNF and NT-4 innervate Meissner corpuscles, a subpopulation of Merkell cells, some mechanoreceptors of the piloneural complex, and the Ruffini's corpuscles; finally, a subpopulation of neurons, which are responsive to NT-3, support postnatal survival of some intraepithelial nerve fibers and Merkel cells in addition to the muscle mechanoreceptors. On the other hand, changes in NTs and NTRs affect the structure of non-nervous structures of the skin and are at the basis of several cutaneous pathologies. This review is an update about the role of NTs and NTRs in the maintenance of normal cutaneous innervation and maintenance of skin integrity. Microsc. Res. Tech. 73:513-529, 2010.
AB - Null mutations of genes from the NGF family of NTs and their receptors (NTRs) lead to loss/reduction of specific neurons in sensory ganglia; conversely, cutaneous overexpression of NTs results in skin hyperinnervation and increase or no changes in the number of sensory neurons innervating the skin. These neuronal changes are paralleled with loss of specific types of sensory nerve formations in the skin. Therefore, mice carrying mutations in NT or NTR genes represent an ideal model to identify the neuronal dependence of each type of cutaneous sensory nerve ending from a concrete subtype of sensory neuron, since the development, maintenance, and structural integrity of sensory nerve formations depend upon sensory neurons. Results obtained from these mouse strains suggest that TrkA positive neurons are connected to intraepithelial nerve fibers and other sensory nerve formations depending from C and Ad nerve fibers; the neurons expressing TrkB and responding to BDNF and NT-4 innervate Meissner corpuscles, a subpopulation of Merkell cells, some mechanoreceptors of the piloneural complex, and the Ruffini's corpuscles; finally, a subpopulation of neurons, which are responsive to NT-3, support postnatal survival of some intraepithelial nerve fibers and Merkel cells in addition to the muscle mechanoreceptors. On the other hand, changes in NTs and NTRs affect the structure of non-nervous structures of the skin and are at the basis of several cutaneous pathologies. This review is an update about the role of NTs and NTRs in the maintenance of normal cutaneous innervation and maintenance of skin integrity. Microsc. Res. Tech. 73:513-529, 2010.
KW - Knock-out mice
KW - Neurotrophins.
KW - Sensory corpuscles
KW - Transgenic overexpressing mice
KW - Trk neurotrophin receptors.
UR - http://www.scopus.com/inward/record.url?scp=77951855820&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951855820&partnerID=8YFLogxK
U2 - 10.1002/jemt.20790
DO - 10.1002/jemt.20790
M3 - Review article
C2 - 19839059
AN - SCOPUS:77951855820
VL - 73
SP - 513
EP - 529
JO - Microscopy Research and Technique
JF - Microscopy Research and Technique
SN - 1059-910X
IS - 5
ER -