Development and neuronal dependence of cutaneous sensory nerve formations: Lessons from neurotrophins

Juan A. MontañO, Pablo Pérez-Piñera, Olivia GarcíA-Suá Rez, Juan Cobo, Jose A. Vega

Research output: Contribution to journalReview article

Abstract

Null mutations of genes from the NGF family of NTs and their receptors (NTRs) lead to loss/reduction of specific neurons in sensory ganglia; conversely, cutaneous overexpression of NTs results in skin hyperinnervation and increase or no changes in the number of sensory neurons innervating the skin. These neuronal changes are paralleled with loss of specific types of sensory nerve formations in the skin. Therefore, mice carrying mutations in NT or NTR genes represent an ideal model to identify the neuronal dependence of each type of cutaneous sensory nerve ending from a concrete subtype of sensory neuron, since the development, maintenance, and structural integrity of sensory nerve formations depend upon sensory neurons. Results obtained from these mouse strains suggest that TrkA positive neurons are connected to intraepithelial nerve fibers and other sensory nerve formations depending from C and Ad nerve fibers; the neurons expressing TrkB and responding to BDNF and NT-4 innervate Meissner corpuscles, a subpopulation of Merkell cells, some mechanoreceptors of the piloneural complex, and the Ruffini's corpuscles; finally, a subpopulation of neurons, which are responsive to NT-3, support postnatal survival of some intraepithelial nerve fibers and Merkel cells in addition to the muscle mechanoreceptors. On the other hand, changes in NTs and NTRs affect the structure of non-nervous structures of the skin and are at the basis of several cutaneous pathologies. This review is an update about the role of NTs and NTRs in the maintenance of normal cutaneous innervation and maintenance of skin integrity. Microsc. Res. Tech. 73:513-529, 2010.

Original languageEnglish (US)
Pages (from-to)513-529
Number of pages17
JournalMicroscopy research and technique
Volume73
Issue number5
DOIs
StatePublished - May 2010
Externally publishedYes

Fingerprint

Nerve Growth Factors
nerves
neurons
Neurons
Skin
nerve fibers
Mechanoreceptors
Sensory Receptor Cells
mechanoreceptors
maintenance
blood cells
Nerve Fibers
mutations
genes
integrity
mice
Fibers
Maintenance
Genes
Merkel Cells

Keywords

  • Knock-out mice
  • Neurotrophins.
  • Sensory corpuscles
  • Transgenic overexpressing mice
  • Trk neurotrophin receptors.

ASJC Scopus subject areas

  • Anatomy
  • Instrumentation
  • Histology
  • Medical Laboratory Technology

Cite this

Development and neuronal dependence of cutaneous sensory nerve formations : Lessons from neurotrophins. / MontañO, Juan A.; Pérez-Piñera, Pablo; GarcíA-Suá Rez, Olivia; Cobo, Juan; Vega, Jose A.

In: Microscopy research and technique, Vol. 73, No. 5, 05.2010, p. 513-529.

Research output: Contribution to journalReview article

MontañO, Juan A. ; Pérez-Piñera, Pablo ; GarcíA-Suá Rez, Olivia ; Cobo, Juan ; Vega, Jose A. / Development and neuronal dependence of cutaneous sensory nerve formations : Lessons from neurotrophins. In: Microscopy research and technique. 2010 ; Vol. 73, No. 5. pp. 513-529.
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