Determining thresholds for contrast agent collapse

Azzdine Y. Ammi, Jonathan Mamou, Grace I. Wang, Robin O. Cleveland, S. Lori Bridal, William D. O 'Brien

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Determining the threshold of fragmentation of ultrasound contrast agents is important for both imaging and therapeutic ultrasound applications. We detected acoustic emissions from Optison™ microbubbles that were insonified by pulses of ultrasound. Our observations suggest that when the microbubbles rupture, daughter bubbles are created which subsequently grow and then collapse on a time-scale of 1-5 μs. The emission from the "rebound" collapse occurs after the end of the excitation pulse and we used the presence of this signal to determine the thresholds for the shell rupture. These shell-disruption thresholds were found to increase with frequency and decrease with pulse length.

Original languageEnglish (US)
Title of host publicationProceedings - 2004 IEEE Ultrasonics Symposium
Subtitle of host publicationA Conference of the IEEE International Ultrasonics, Ferroelectrics, and Frequency Control Society, UFFC-S
EditorsM.P. Yuhas
Number of pages4
StatePublished - Dec 1 2004
Event2004 IEEE Ultrasonics Symposium - Montreal, Que., Canada
Duration: Aug 23 2004Aug 27 2004

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117


Other2004 IEEE Ultrasonics Symposium
CityMontreal, Que.

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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